All Phenotypes Slc6a9<tm1Veul> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Slc6a9^tm1Veul
targeted mutation 1, Volker Eulenburg
MGI:4818447

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc6a9^tm1Veul/Slc6a9^tm1Veul	involves: 129P2/OlaHsd	MGI:4818485
cn2	Slc6a9^tm1Veul/Slc6a9^tm1Veul Tg(Syn1-cre)671Jxm/?	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:4818488
cn3	Slc6a9^tm1Veul/Slc6a9^tm1Veul Tg(EIIa-cre)C5379Lmgd/?	involves: 129P2/OlaHsd * FVB/N	MGI:4818487
cn4	Slc6a9^tm1Veul/Slc6a9^tm1Veul Tg(Gfap-cre)2Brn/?	involves: 129P2/OlaHsd * FVB/N	MGI:4818489

Allelic Composition	Slc6a9^tm1Veul/Slc6a9^tm1Veul
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a9^tm1Veul mutation (0 available); any Slc6a9 mutation (24 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:161993 )

Allelic Composition	Slc6a9^tm1Veul/Slc6a9^tm1Veul Tg(Syn1-cre)671Jxm/?
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a9^tm1Veul mutation (0 available); any Slc6a9 mutation (24 available)
Tg(Syn1-cre)671Jxm mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:161993 )

N	• no hypotonia

behavior/neurological

behavior/neurological phenotype ( J:161993 )

N	• no motor defects seen in open field or rotarod tests

nervous system

abnormal neuron physiology ( J:161993 )

• GlyT1 specific uptake of glycine by hippocampal membranes is reduced 50%

Allelic Composition	Slc6a9^tm1Veul/Slc6a9^tm1Veul Tg(EIIa-cre)C5379Lmgd/?
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a9^tm1Veul mutation (0 available); any Slc6a9 mutation (24 available)
Tg(EIIa-cre)C5379Lmgd mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:161993 )

• die within 8 hours of birth

muscle

hypotonia ( J:161993 )

behavior/neurological

abnormal motor capabilities/coordination/movement ( J:161993 )

Allelic Composition	Slc6a9^tm1Veul/Slc6a9^tm1Veul Tg(Gfap-cre)2Brn/?
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc6a9^tm1Veul mutation (0 available); any Slc6a9 mutation (24 available)
Tg(Gfap-cre)2Brn mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:161993 )

• hypotonic phenotype leads to premature death

• frequency of deaths peaks at around 3 days of age

• 20% of mice have a normal life span

muscle

hypotonia ( J:161993 )

• 80% of homozygotes show a strong hypotonic phenotype

• onset from day 1 through 10 days of age

• 20% of mice develop no phenotype

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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