Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MagohMos2 mutation
(0 available);
any
Magoh mutation
(15 available)
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Allelic
Composition |
MagohMos2/Magoh+
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Genetic
Background |
involves: BALB/cJ * C57BL/6 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MagohMos2 mutation
(0 available);
any
Magoh mutation
(15 available)
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nervous system
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• at E16.5, cortical thickness is ~50% that of wild-type controls
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Allelic
Composition |
MagohMos2/Magoh+
|
|
Genetic
Background |
involves: BALB/cJ * C57BL/6J |
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
MagohMos2 mutation
(0 available);
any
Magoh mutation
(15 available)
|
|
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embryo
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• at E13.5, heterozygotes show a mild developmental delay relative to wild-type controls
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mortality/aging
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• premature death occurs before weaning in some animals
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• before weaning with incomplete penetrance
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pigmentation
growth/size/body
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• at E13.5, heterozygotes show a mild developmental delay relative to wild-type controls
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• 33% smaller than control littermates
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nervous system
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• most ectopically produced neurons undergo apoptosis
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• brains exhibit extensive apoptosis in the cortex at E14.5
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• ectopic and precocious neurogenesis resulting in expanded calretinin-positive cells and ectopically produced Cajal Retzius cells in cortex
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• at E18.5 the cortical layers were thinner and disorganized
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• adult brain weighed significantly less than those of control littermates
(J:159625)
• present prenatally starting between E12.5 and E18.5
(J:159625)
• at E18.5, brain size is disproportionally reduced by 30% relative to body size
(J:240595)
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• forebrain size is significantly reduced at E18.5
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• neocortex size is disproportionally decreased at E13.5
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• intermediate neural progenitors in developing cortex was markedly reduced resulting in the smaller number of neurons in E18.5 brains
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• brains show ectopic neuron differentiation at E12.5
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cellular
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• abnormal orientation of the neural stem cell mitotic division plane during cortex development
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• most ectopically produced neurons undergo apoptosis
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• brains exhibit extensive apoptosis in the cortex at E14.5
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• ectopic and precocious neurogenesis resulting in expanded calretinin-positive cells and ectopically produced Cajal Retzius cells in cortex
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Analysis Tools
