All Phenotypes Chtf18<tm1.1KhK> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Chtf18^tm1.1KhK
targeted mutation 1.1, Klaus H Kaestner
MGI:4462054

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Chtf18^tm1.1KhK/Chtf18^tm1.1KhK	Not Specified	MGI:4462055
cn2	Chtf18^tm1.1KhK/Chtf18^tm1.2Khk Alpl^tm1(cre)Nagy/Alpl⁺	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5473610

Allelic Composition	Chtf18^tm1.1KhK/Chtf18^tm1.1KhK
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chtf18^tm1.1KhK mutation (0 available); any Chtf18 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Small testes in Chtf18^tm1.1KhK/Chtf18^tm1.1KhK mice

mortality/aging

prenatal lethality, incomplete penetrance ( J:194119 )

• fewer than expected mice are present at E14.5 to E18.5

reproductive system

abnormal male germ cell morphology ( J:194119 )

• reduced prospermatogonia

increased male germ cell apoptosis ( J:194119 )

decreased testis weight ( J:194119 )

abnormal spermatogenesis ( J:194119 )

oligozoospermia ( J:194119 )

• reduced more than 5-fold

abnormal male meiosis ( J:194119 )

• homologous chromosomes separate prematurely

• early disjunction persists into metaphase I

• defective meiotic recombination that persist into late stages

reduced male fertility ( J:194119 )

growth/size/body

decreased body weight ( J:194119 )

cellular

abnormal male germ cell morphology ( J:194119 )

• reduced prospermatogonia

oligozoospermia ( J:194119 )

• reduced more than 5-fold

increased male germ cell apoptosis ( J:194119 )

endocrine/exocrine glands

decreased testis weight ( J:194119 )

Allelic Composition	Chtf18^tm1.1KhK/Chtf18^tm1.2Khk Alpl^tm1(cre)Nagy/Alpl⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpl^tm1(cre)Nagy mutation (6 available); any Alpl mutation (351 available)
Chtf18^tm1.1KhK mutation (0 available); any Chtf18 mutation (34 available)
Chtf18^tm1.2Khk mutation (0 available); any Chtf18 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

abnormal male germ cell morphology ( J:194119 )

• abnormal spermatogenic cells as in Chtf18^tm1.1Khk homozygotes

cellular

abnormal male germ cell morphology ( J:194119 )

• abnormal spermatogenic cells as in Chtf18^tm1.1Khk homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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