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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Chtf18tm1.1KhK
targeted mutation 1.1, Klaus H Kaestner
MGI:4462054
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Chtf18tm1.1KhK/Chtf18tm1.1KhK Not Specified MGI:4462055
cn2
 		Chtf18tm1.1KhK/Chtf18tm1.2Khk
Alpltm1(cre)Nagy/Alpl+ 		involves: 129S1/Sv * 129X1/SvJ * FVB/N MGI:5473610


Genotype
MGI:4462055
hm1
Allelic
Composition		 Chtf18tm1.1KhK/Chtf18tm1.1KhK
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chtf18tm1.1KhK mutation (1 available); any Chtf18 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Small testes in Chtf18tm1.1KhK/Chtf18tm1.1KhK mice

mortality/aging
prenatal lethality, incomplete penetrance ( J:194119 )
• fewer than expected mice are present at E14.5 to E18.5

reproductive system
abnormal male germ cell morphology ( J:194119 )
• reduced prospermatogonia
oligozoospermia ( J:194119 )
• reduced more than 5-fold
abnormal male meiosis ( J:194119 )
• homologous chromosomes separate prematurely
• early disjunction persists into metaphase I
• defective meiotic recombination that persist into late stages

growth/size/body
decreased body weight ( J:194119 )

cellular
abnormal male germ cell morphology ( J:194119 )
• reduced prospermatogonia
oligozoospermia ( J:194119 )
• reduced more than 5-fold
abnormal male meiosis ( J:194119 )
• homologous chromosomes separate prematurely
• early disjunction persists into metaphase I
• defective meiotic recombination that persist into late stages

endocrine/exocrine glands




Genotype
MGI:5473610
cn2
Allelic
Composition		 Chtf18tm1.1KhK/Chtf18tm1.2Khk
Alpltm1(cre)Nagy/Alpl+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Alpltm1(cre)Nagy mutation (6 available); any Alpl mutation (350 available)
Chtf18tm1.1KhK mutation (1 available); any Chtf18 mutation (36 available)
Chtf18tm1.2Khk mutation (1 available); any Chtf18 mutation (36 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
abnormal male germ cell morphology ( J:194119 )
• abnormal spermatogenic cells as in Chtf18tm1.1Khk homozygotes

cellular
abnormal male germ cell morphology ( J:194119 )
• abnormal spermatogenic cells as in Chtf18tm1.1Khk homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory