Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccna2tm1.1Pisc mutation
(0 available);
any
Ccna2 mutation
(15 available)
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cellular
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• fibroblast cells treated with cre-expressing retroviruses exhibit an increase in the fraction of cells in the S and G2/M phase with a decrease in the G1 phase population compared with cells from wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccna1tm1Djw mutation
(0 available);
any
Ccna1 mutation
(28 available)
Ccna2tm1.1Pisc mutation
(0 available);
any
Ccna2 mutation
(15 available)
Ccna2tm1.2Pisc mutation
(0 available);
any
Ccna2 mutation
(15 available)
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cellular
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• cre-transduced embryonic stem cells fail to proliferate unlike similarly treated double heterozygous cells
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccna1tm1Djw mutation
(0 available);
any
Ccna1 mutation
(28 available)
Ccna2tm1.1Pisc mutation
(0 available);
any
Ccna2 mutation
(15 available)
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hematopoietic system
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• hematopoietic stem cells transduced with cre fail to proliferate and fail to form colonies unlike similarly treated double heterozygous cells
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• hematopoietic stem cells transduced with cre fail to proliferate and fail to form colonies unlike similarly treated double heterozygous cells
|
cellular
|
• fibroblast cells treated with cre-expressing retroviruses exhibit an increase in the fraction o cells in the S and G2/M phase with a decrease in the G1 phase population compared with cells from wild-type mice
|
|
• cre-transduced embryonic stem cells fail to proliferate unlike similarly treated double heterozygous cells
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccna1tm1Djw mutation
(0 available);
any
Ccna1 mutation
(28 available)
Ccna2tm1.1Pisc mutation
(0 available);
any
Ccna2 mutation
(15 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
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mortality/aging
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• pIpC-treated mice die within 30 days
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hematopoietic system
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• in pIpC-treated mice (including CFU-G, CFU-M, CFU-GM, and CFU-GEMM)
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• severe in pIpC-treated mice
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• pIpC-treated mice exhibit a reduction of common myeloid progenitors (CMP), granulocyte-macrophage progenitors (GMP), and megakaryocyte-erythroid progenitors (MEP) compared with similarly treated control mice
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immune system
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccna2tm1.1Pisc mutation
(0 available);
any
Ccna2 mutation
(15 available)
Tg(Mx1-cre)1Cgn mutation
(7 available)
|
|
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mortality/aging
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• pIpC-treated mice die within 30 days
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