Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(10Prmt2-Pdxk)2Yey mutation
(3 available);
any
Dp(10Prmt2-Pdxk)2Yey mutation
(3 available)
Dp(16Lipi-Zbtb21)1Yey mutation
(3 available);
any
Dp(16Lipi-Zbtb21)1Yey mutation
(3 available)
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mortality/aging
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• rate of neonatal lethality is similar to mice hemizygous for Dp(16Lipi-Zfp295)1Yey alone
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(10Prmt2-Pdxk)2Yey mutation
(3 available);
any
Dp(10Prmt2-Pdxk)2Yey mutation
(3 available)
Dp(16Lipi-Zbtb21)1Yey mutation
(3 available);
any
Dp(16Lipi-Zbtb21)1Yey mutation
(3 available)
Dp(17Abcg1-Rrp1b)3Yey mutation
(3 available);
any
Dp(17Abcg1-Rrp1b)3Yey mutation
(3 available)
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mortality/aging
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• mice with hydrocephaly die around 6 to 8 weeks of age
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• mice with hydrocephaly die around 6 to 8 weeks of age
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• about 26% die soon after birth
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behavior/neurological
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• freeze significantly less when returned to the test chamber 24 h or 72 h after initial training and foot shock
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• display a longer latency and a longer path length to reach the hidden platform in a Morris water maze
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• in a Morris water maze probe test mice spend less time in the target quadrant
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• decrease in swimming speed
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nervous system
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• seen in about 6.5% of mice, associated with aqueductal stenosis
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• in mice with hydrocephaly
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cardiovascular system
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• display heart defects at a similar frequency to mice hemizygous for Dp(16Lipi-Zfp295)1Yey alone
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reproductive system
N |
• unlike mice carrying Ts(17<16>)65Dn , no reproductive impairment is seen in mice even when put on an inbred background
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(10Prmt2-Pdxk)2Yey mutation
(3 available);
any
Dp(10Prmt2-Pdxk)2Yey mutation
(3 available)
Dp(17Abcg1-Rrp1b)3Yey mutation
(3 available);
any
Dp(17Abcg1-Rrp1b)3Yey mutation
(3 available)
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mortality/aging
N |
• unlike mice carrying Dp(16Lipi-Zfp295)1Yey , no increase in neonatal lethality relative to wild-type controls is detected
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dp(10Prmt2-Pdxk)2Yey mutation
(3 available);
any
Dp(10Prmt2-Pdxk)2Yey mutation
(3 available)
|
|
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mortality/aging
N |
• unlike mice carrying Dp(16Lipi-Zfp295)1Yey , no increase in neonatal lethality relative to wild-type controls is detected
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