Phenotypes associated with this allele

• Allele Symbol: Hoxa3^tm1Nrm
• Allele Name: targeted mutation 1, Nancy R Manley
• Allele ID: MGI:4461254
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Hoxa3^tm1Nrm/Hoxa3^tm1Nrm	involves: C3H * C57BL/6 * C57BL/6NHsd	MGI:4461320
ht2	Hoxa3^tm1Nrm/Hoxa3^tm1Mrc	involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6NHsd	MGI:4461319

Genotype
MGI:4461320

hm1

• Allelic Composition: Hoxa3^tm1Nrm/Hoxa3^tm1Nrm
• Genetic Background: involves: C3H * C57BL/6 * C57BL/6NHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality ( J:161296 )

craniofacial

craniofacial phenotype ( J:161296 )

N • mice exhibit a normal soft palate

abnormal hyoid bone greater horn morphology ( J:161296 )

• the greater horn of the hyoid bone is malformed and fused to the thyroid cartilage unlike in wild-type mice

abnormal hyoid bone lesser horn morphology ( J:161296 )

• the lesser horn of the hyoid bone has a tear drop shape and is fused to the great horn unlike in wild-type mice

nervous system

abnormal glossopharyngeal nerve morphology ( J:161296 )

• the glossopharyngeal nerve is either fused to the vagus nerve or disconnected from the hind brain unlike in wild-type mice

fusion of glossopharyngeal and vagus nerve ( J:161296 )

• in some mice

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:161296 )

N • unlike in null mice, the ventral thyroid isthmus is normal

absent parathyroid glands ( J:161296 )

athymia ( J:161296 )

immune system

athymia ( J:161296 )

digestive/alimentary system

digestive/alimentary phenotype ( J:161296 )

N • mice exhibit a normal soft palate

skeleton

abnormal hyoid bone greater horn morphology ( J:161296 )

• the greater horn of the hyoid bone is malformed and fused to the thyroid cartilage unlike in wild-type mice

abnormal hyoid bone lesser horn morphology ( J:161296 )

• the lesser horn of the hyoid bone has a tear drop shape and is fused to the great horn unlike in wild-type mice

growth/size/body

growth/size/body region phenotype ( J:161296 )

N • mice exhibit a normal abdomen

hematopoietic system

athymia ( J:161296 )

respiratory system

respiratory system phenotype ( J:161296 )

N • unlike in null mice, tracheal epithelia is normal

Genotype
MGI:4461319

ht2

• Allelic Composition: Hoxa3^tm1Nrm/Hoxa3^tm1Mrc
• Genetic Background: involves: 129S7/SvEvBrd * C3H * C57BL/6 * C57BL/6NHsd

mortality/aging

neonatal lethality ( J:161296 )

craniofacial

abnormal hyoid bone greater horn morphology ( J:161296 )

abnormal hyoid bone lesser horn morphology ( J:161296 )

abnormal soft palate morphology ( J:161296 )

• mice exhibit a partial rescue of velum length compared with Hoxa3^tm1Mrc homozygotes

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:161296 )

N • unlike in null mice, the ventral thyroid isthmus is normal

absent parathyroid glands ( J:161296 )

athymia ( J:161296 )

nervous system

abnormal glossopharyngeal nerve morphology ( J:161296 )

• the glossopharyngeal nerve is either fused to the vagus nerve or disconnected from the hind brain unlike in wild-type mice

fusion of glossopharyngeal and vagus nerve ( J:161296 )

• in some mice

immune system

athymia ( J:161296 )

growth/size/body

abnormal soft palate morphology ( J:161296 )

• mice exhibit a partial rescue of velum length compared with Hoxa3^tm1Mrc homozygotes

distended abdomen ( J:161296 )

• bloated due to breathing air into the esophagus

respiratory system

respiratory system phenotype ( J:161296 )

N • unlike in null mice, tracheal epithelia is normal

skeleton

abnormal hyoid bone greater horn morphology ( J:161296 )

abnormal hyoid bone lesser horn morphology ( J:161296 )

digestive/alimentary system

abnormal soft palate morphology ( J:161296 )

• mice exhibit a partial rescue of velum length compared with Hoxa3^tm1Mrc homozygotes

hematopoietic system

athymia ( J:161296 )