• impaired myelination in adolescent and adult mice with hypomyelination in the corpus callosum splenium, hippocampus, and cerebral cortex, and in the ventral and dorsal horns of the spinal cord and a small reduction in the thymus of adolescent mice but not adults
• however, no differences in myelination in the cerebellum and in Purkinje cell number
• fractional anisotropy is reduced in the anterior commissure, corpus callosum genu and splenium, and the optic tract due to increased radial diffusivity in the absence of effects on axial diffusivity, suggesting a myelin deficiency in these regions
• the optic nerve shows no change in fractional anisotropy but reduced radial diffusivity, axial diffusivity, and mean diffusivity
• mice show an increase in the number of unmyelinated axons with cross-sectional axons greater than the smaller myelinated axons in wild-type mice