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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Olig2tm1.1(cre)Wdr
targeted mutation 1.1, William D Richardson
MGI:4461156
Summary 8 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Acvr1tm1Mak/Acvr1+
Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Olig2tm1.1(cre)Wdr/Olig2+
involves: 129 * C57BL/6 MGI:6414954
cn2
Acvr1tm1Mak/Acvr1+
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
H3c2tm1Mak/H3c2+
Olig2tm1.1(cre)Wdr/Olig2+
involves: 129 * C57BL/6 * FVB/N MGI:6414961
cn3
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Olig2tm1.1(cre)Wdr/Olig2+
involves: 129 * C57BL/6 * FVB/N MGI:6414962
cn4
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
H3c2tm1Mak/H3c2+
Olig2tm1.1(cre)Wdr/Olig2+
involves: 129 * C57BL/6 * FVB/N MGI:6414963
cn5
Acvr1tm1Mak/Acvr1+
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Olig2tm1.1(cre)Wdr/Olig2+
involves: 129 * C57BL/6 * FVB/N MGI:6414964
cn6
Acvr1tm1Mak/Acvr1+
Olig2tm1.1(cre)Wdr/Olig2+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:6414951
cn7
Acvr1tm1Mak/Acvr1+
H3c2tm1Mak/H3c2+
Olig2tm1.1(cre)Wdr/Olig2+
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:6414958
cn8
Polr3atm1Iwil/Polr3atm1Iwil
Olig2tm1.1(cre)Wdr/Olig2+
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:8187957


Genotype
MGI:6414954
cn1
Allelic
Composition
Acvr1tm1Mak/Acvr1+
Gt(ROSA)26Sortm9(CAG-tdTomato)Hze/Gt(ROSA)26Sor+
Olig2tm1.1(cre)Wdr/Olig2+
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Mak mutation (0 available); any Acvr1 mutation (43 available)
Gt(ROSA)26Sortm9(CAG-tdTomato)Hze mutation (7 available); any Gt(ROSA)26Sor mutation (1098 available)
Olig2tm1.1(cre)Wdr mutation (1 available); any Olig2 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• 2-fold increase in the number of oligodendroglial cells in the ventral brainstem at P7 and P21

cellular
• 2-fold increase in the number of oligodendroglial cells in the ventral brainstem at P7 and P21




Genotype
MGI:6414961
cn2
Allelic
Composition
Acvr1tm1Mak/Acvr1+
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
H3c2tm1Mak/H3c2+
Olig2tm1.1(cre)Wdr/Olig2+
Genetic
Background
involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Mak mutation (0 available); any Acvr1 mutation (43 available)
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation (2 available); any Gt(ROSA)26Sor mutation (1098 available)
H3c2tm1Mak mutation (0 available); any H3c2 mutation (7 available)
Olig2tm1.1(cre)Wdr mutation (1 available); any Olig2 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• most mice succumb to spontaneous brain tumors, with a median survival of 419 days
• tumors are high-grade diffuse gliomas
• tumors often infiltrate throughout many parts of the brain, particularly in the midbrain and thalamic regions
• tumors express markers of oligodendroglial origin

nervous system
• most mice succumb to spontaneous brain tumors, with a median survival of 419 days
• tumors are high-grade diffuse gliomas
• tumors often infiltrate throughout many parts of the brain, particularly in the midbrain and thalamic regions
• tumors express markers of oligodendroglial origin

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
brain glioma DOID:0060108 J:285841




Genotype
MGI:6414962
cn3
Allelic
Composition
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Olig2tm1.1(cre)Wdr/Olig2+
Genetic
Background
involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation (2 available); any Gt(ROSA)26Sor mutation (1098 available)
Olig2tm1.1(cre)Wdr mutation (1 available); any Olig2 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• mice do not develop brain tumors




Genotype
MGI:6414963
cn4
Allelic
Composition
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
H3c2tm1Mak/H3c2+
Olig2tm1.1(cre)Wdr/Olig2+
Genetic
Background
involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation (2 available); any Gt(ROSA)26Sor mutation (1098 available)
H3c2tm1Mak mutation (0 available); any H3c2 mutation (7 available)
Olig2tm1.1(cre)Wdr mutation (1 available); any Olig2 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
N
• mice do not develop brain tumors




Genotype
MGI:6414964
cn5
Allelic
Composition
Acvr1tm1Mak/Acvr1+
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan/Gt(ROSA)26Sor+
Olig2tm1.1(cre)Wdr/Olig2+
Genetic
Background
involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Mak mutation (0 available); any Acvr1 mutation (43 available)
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation (2 available); any Gt(ROSA)26Sor mutation (1098 available)
Olig2tm1.1(cre)Wdr mutation (1 available); any Olig2 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
neoplasm
• most mice succumb to spontaneous brain tumors
• tumors are high-grade diffuse gliomas

nervous system
• most mice succumb to spontaneous brain tumors
• tumors are high-grade diffuse gliomas

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
brain glioma DOID:0060108 J:285841




Genotype
MGI:6414951
cn6
Allelic
Composition
Acvr1tm1Mak/Acvr1+
Olig2tm1.1(cre)Wdr/Olig2+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Mak mutation (0 available); any Acvr1 mutation (43 available)
Olig2tm1.1(cre)Wdr mutation (1 available); any Olig2 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• some mice fail to gain normal body weight and die before weaning

behavior/neurological
• surviving mice show moderate ataxia

muscle
• surviving mice show spasms when disrupted during rest

nervous system
• glial cells exhibit increased growth
• marker analysis indicates the differentiation of oligodendroglial lineage cells is blocked and neuroglial progenitors are upregulated
• higher density of PDGFRA+ cells in brainstems

neoplasm
N
• mice do not develop tumors

cellular
• glial cells exhibit increased growth




Genotype
MGI:6414958
cn7
Allelic
Composition
Acvr1tm1Mak/Acvr1+
H3c2tm1Mak/H3c2+
Olig2tm1.1(cre)Wdr/Olig2+
Genetic
Background
involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Mak mutation (0 available); any Acvr1 mutation (43 available)
H3c2tm1Mak mutation (0 available); any H3c2 mutation (7 available)
Olig2tm1.1(cre)Wdr mutation (1 available); any Olig2 mutation (45 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• partial early postnatal lethality

neoplasm
N
• mice do not develop brain tumors




Genotype
MGI:8187957
cn8
Allelic
Composition
Polr3atm1Iwil/Polr3atm1Iwil
Olig2tm1.1(cre)Wdr/Olig2+
Genetic
Background
involves: 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Olig2tm1.1(cre)Wdr mutation (1 available); any Olig2 mutation (45 available)
Polr3atm1Iwil mutation (0 available); any Polr3a mutation (70 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• approximately 60% of females fail to differentiate between familiar and novel objects in the object recognition test
• more than 60% of male and approximately 80% of females fail to differentiation between familiar and novel objects in object placement test
• more than 60% of male and approximately 80% of females fail to differentiation between familiar and novel objects in object placement test
• males exhibit a reduction in the magnitude of the startle reflex at all stimulus intensities
• females exhibit a trend in reduced startle reflex at lower stimuli and significant reduction at 115 dB
• both males and females show a delay to elicit a startle reflex at 115 dB
• in the Hargreaves test of reflex response to thermal sensation, mice show normal increased latency for hind paw withdrawal as a function of stimulus intensity, however the relative response is delayed at lower intensities for males and at all intensities for females, suggesting an impaired sensation and reflex response
• mice show a delay in achieving developmental milestones such as deficits in body-righting mechanisms, strength, coordination, locomotion and the extinguishing of pivoting behavior

growth/size/body
• smaller body size throughout adolescence, with males showing decreased size at 3, 4, and 5 weeks of age and females at 4 and 5 weeks of age
• adults exhibit decreased body weight; body weight difference is maintained in males and is enhanced in females between 3 and 5 weeks of age and differences in body weight are seen at 12 and 16 weeks of age
• mice show reduced weight gain after birth, with body weight difference that is more pronounced in males and increases over time from P5 to P21, in contrast to females that maintain a relatively constant and smaller body weight difference

nervous system
• adolescent and adult mice exhibit reduced numbers of myelinating oligodendrocytes
• adolescent males show a reduction in O4 and MOG double-positive premyelinating- oligodendrocytes while females show only a trend in this reduction
• reduced myelin thickness is seen across a range of axon calibers, indicating a defect in the capacity of mature oligodendrocytes to produce a myelin sheath of normal thickness
• reduction in the size of the white matter tract due to the projection of the ventral horns into the ventrolateral funiculus
• myelin sheath thickness is reduced as indicated by a higher average g-ratio
• reduced myelin thickness is seen across a range of axon calibers
• impaired myelination in adolescent and adult mice with hypomyelination in the corpus callosum splenium, hippocampus, and cerebral cortex, and in the ventral and dorsal horns of the spinal cord and a small reduction in the thymus of adolescent mice but not adults
• however, no differences in myelination in the cerebellum and in Purkinje cell number
• fractional anisotropy is reduced in the anterior commissure, corpus callosum genu and splenium, and the optic tract due to increased radial diffusivity in the absence of effects on axial diffusivity, suggesting a myelin deficiency in these regions
• the optic nerve shows no change in fractional anisotropy but reduced radial diffusivity, axial diffusivity, and mean diffusivity
• mice show an increase in the number of unmyelinated axons with cross-sectional axons greater than the smaller myelinated axons in wild-type mice

cellular
• adolescent and adult mice exhibit reduced numbers of myelinating oligodendrocytes
• adolescent males show a reduction in O4 and MOG double-positive premyelinating- oligodendrocytes while females show only a trend in this reduction
• reduced myelin thickness is seen across a range of axon calibers, indicating a defect in the capacity of mature oligodendrocytes to produce a myelin sheath of normal thickness

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hypomyelinating leukodystrophy 7 DOID:0060794 OMIM:607694
J:311745





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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory