Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Mak mutation
(0 available);
any
Acvr1 mutation
(44 available)
Gt(ROSA)26Sortm9(CAG-tdTomato)Hze mutation
(4 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Olig2tm1.1(cre)Wdr mutation
(1 available);
any
Olig2 mutation
(46 available)
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nervous system
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• 2-fold increase in the number of oligodendroglial cells in the ventral brainstem at P7 and P21
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Mak mutation
(0 available);
any
Acvr1 mutation
(44 available)
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation
(2 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Olig2tm1.1(cre)Wdr mutation
(1 available);
any
Olig2 mutation
(46 available)
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neoplasm
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• most mice succumb to spontaneous brain tumors
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• tumors are high-grade diffuse gliomas
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nervous system
|
• most mice succumb to spontaneous brain tumors
|
|
• tumors are high-grade diffuse gliomas
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Mak mutation
(0 available);
any
Acvr1 mutation
(44 available)
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation
(2 available);
any
Gt(ROSA)26Sor mutation
(942 available)
H3c2tm1Mak mutation
(0 available);
any
H3c2 mutation
(7 available)
Olig2tm1.1(cre)Wdr mutation
(1 available);
any
Olig2 mutation
(46 available)
|
|
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neoplasm
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• most mice succumb to spontaneous brain tumors, with a median survival of 419 days
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• tumors are high-grade diffuse gliomas
• tumors often infiltrate throughout many parts of the brain, particularly in the midbrain and thalamic regions
• tumors express markers of oligodendroglial origin
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nervous system
|
• most mice succumb to spontaneous brain tumors, with a median survival of 419 days
|
|
• tumors are high-grade diffuse gliomas
• tumors often infiltrate throughout many parts of the brain, particularly in the midbrain and thalamic regions
• tumors express markers of oligodendroglial origin
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation
(2 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Olig2tm1.1(cre)Wdr mutation
(1 available);
any
Olig2 mutation
(46 available)
|
|
|
neoplasm
N |
• mice do not develop brain tumors
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Pik3ca*H1047R)Egan mutation
(2 available);
any
Gt(ROSA)26Sor mutation
(942 available)
H3c2tm1Mak mutation
(0 available);
any
H3c2 mutation
(7 available)
Olig2tm1.1(cre)Wdr mutation
(1 available);
any
Olig2 mutation
(46 available)
|
|
|
neoplasm
N |
• mice do not develop brain tumors
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Mak mutation
(0 available);
any
Acvr1 mutation
(44 available)
Olig2tm1.1(cre)Wdr mutation
(1 available);
any
Olig2 mutation
(46 available)
|
|
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mortality/aging
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• some mice fail to gain normal body weight and die before weaning
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behavior/neurological
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• surviving mice show moderate ataxia
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muscle
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• surviving mice show spasms when disrupted during rest
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nervous system
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• marker analysis indicates the differentiation of oligodendroglial lineage cells is blocked and neuroglial progenitors are upregulated
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• higher density of PDGFRA+ cells in brainstems
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• glial cells exhibit increased growth
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neoplasm
N |
• mice do not develop tumors
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Acvr1tm1Mak mutation
(0 available);
any
Acvr1 mutation
(44 available)
H3c2tm1Mak mutation
(0 available);
any
H3c2 mutation
(7 available)
Olig2tm1.1(cre)Wdr mutation
(1 available);
any
Olig2 mutation
(46 available)
|
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mortality/aging
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• partial early postnatal lethality
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neoplasm
N |
• mice do not develop brain tumors
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