Phenotypes associated with this allele

• Allele Symbol: G6pc2^tm1.1Pesa
• Allele Name: targeted mutation 1.1, Pere Santamaria
• Allele ID: MGI:4461063
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	G6pc2^tm1.1Pesa/G6pc2^tm1.1Pesa	NOD.129S2-G6pc2^tm1.1Pesa	MGI:4461133

Genotype
MGI:4461133

hm1

• Allelic Composition: G6pc2^tm1.1Pesa/G6pc2^tm1.1Pesa
• Genetic Background: NOD.129S2-G6pc2^tm1.1Pesa

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:160286 )

N • mice develop type 1 diabetes with the same incidence curve of NOD mice

decreased T cell proliferation ( J:160286 )

• naive G6PC206-214-reactive Tg(TcraTcrbNY8.3)1Pesa CD8+ T cells fail to proliferate in the pancreatic lymph nodes unlike in NOD mice

abnormal CD8-positive, alpha beta T cell morphology ( J:160286 )

• mice lack G6PC206-214-reactive CD8+ T cells unlike similarly treated NOD mice

abnormal CD8-positive, alpha-beta T cell physiology ( J:160286 )

• mice exhibit impaired recruitment of naive and preactivated G6PC206-214-reactive Tg(TcraTcrbNY8.3)1Pesa CD8+ T cells to inflamed islets compared with similarly treated NOD mice

decreased interferon-gamma secretion ( J:160286 )

• islet-associated T cells from prediabetic mice do not produce IFN-gamma in response to NRP-V7 peptide-pulsed antigen producing cells unlike similarly treated NOD cells

hematopoietic system

decreased T cell proliferation ( J:160286 )

• naive G6PC206-214-reactive Tg(TcraTcrbNY8.3)1Pesa CD8+ T cells fail to proliferate in the pancreatic lymph nodes unlike in NOD mice

abnormal CD8-positive, alpha beta T cell morphology ( J:160286 )

• mice lack G6PC206-214-reactive CD8+ T cells unlike similarly treated NOD mice

abnormal CD8-positive, alpha-beta T cell physiology ( J:160286 )

• mice exhibit impaired recruitment of naive and preactivated G6PC206-214-reactive Tg(TcraTcrbNY8.3)1Pesa CD8+ T cells to inflamed islets compared with similarly treated NOD mice

cellular

decreased T cell proliferation ( J:160286 )

• naive G6PC206-214-reactive Tg(TcraTcrbNY8.3)1Pesa CD8+ T cells fail to proliferate in the pancreatic lymph nodes unlike in NOD mice