G6pc2^tm1.1Pesa
Targeted Allele Detail

Summary

• Symbol: G6pc2^tm1.1Pesa
• Name: glucose-6-phosphatase, catalytic, 2; targeted mutation 1.1, Pere Santamaria
• MGI ID: MGI:4461063
• Synonyms: IGRP^{K209A/F213A-KI}
• Gene: G6pc2 Location: Chr2:69041417-69058185 bp, + strand Genetic Position: Chr2, 39.66 cM
• Alliance: G6pc2^tm1.1Pesa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:160286
• Parent Cell Line: CK35 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

Allele Type: Targeted (Not Applicable) Mutations: Insertion, Nucleotide substitutions Mutation details: Exon 5 was replaced with an frt flanked neo cassette and a modified exon 5 in which nucleotide substitutions result in the amino acid substitutions of alanine for lysine at position 209 (K209A) and alanine for phenylalanine at position 213 (F213A). Flp mediated recombination removed the neo cassette leaving a single frt site downstream of the modified exon 5. The modified residues participate in T cell receptor contact. (J:160286)

Generation of the G6pc2^tm1.1Pesa allele

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any G6pc2 Mutation: 24 strains or lines available

References

• Original: J:160286 Wang J, et al., In situ recognition of autoantigen as an essential gatekeeper in autoimmune CD8+ T cell inflammation. Proc Natl Acad Sci U S A. 2010 May 18;107(20):9317-22
• All: 7 reference(s)