Phenotypes associated with this allele

• Allele Symbol: Gt(ROSA)26Sor^{tm1(ITK/SYK)Jrld}
• Allele Name: targeted mutation 1, Jurgen Ruland
• Allele ID: MGI:4460818
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Cd19^tm1(cre)Cgn/Cd19^+ Gt(ROSA)26Sor^tm1(ITK/SYK)Jrld/Gt(ROSA)26Sor^+	involves: 129P2/OlaHsd	MGI:4460905
cn2	Gt(ROSA)26Sor^tm1(ITK/SYK)Jrld/Gt(ROSA)26Sor^+ Tg(Cd4-cre)1Cwi/0	involves: 129P2/OlaHsd * C57BL/6 * DBA/2	MGI:4460904

Genotype
MGI:4460905

cn1

• Allelic Composition: Cd19^tm1(cre)Cgn/Cd19⁺; Gt(ROSA)26Sor^{tm1(ITK/SYK)Jrld}/Gt(ROSA)26Sor⁺
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Enlarged spleen and solid organ infiltration with abnormally proliferating T cells in Gt(ROSA)26Sor^{tm1(ITK/SYK)Jrld}/Gt(ROSA)26Sor⁺ Cd19^tm1(cre)Cgn/Cd19⁺ mice

mortality/aging

premature death ( J:160931 )

• mice develop lethal wasting and die by 60 weeks of age unlike wild-type mice

immune system

increased T cell derived lymphoma incidence ( J:160931 )

• mice develop infiltrating lymphocytes into multiple organs unlike in wild-type mice

• lymphomas consists of enlarged, activated, and highly proliferative T cells

enlarged spleen ( J:160931 )

• at 50 weeks

abnormal T cell activation ( J:160931 )

• lymphomas consists of enlarged, activated, and highly proliferative T cells

increased T cell proliferation ( J:160931 )

• lymphomas consists of enlarged, activated, and highly proliferative T cells

neoplasm

increased T cell derived lymphoma incidence ( J:160931 )

• mice develop infiltrating lymphocytes into multiple organs unlike in wild-type mice

• lymphomas consists of enlarged, activated, and highly proliferative T cells

growth/size/body

cachexia ( J:160931 )

• mice develop lethal wasting unlike wild-type mice

enlarged spleen ( J:160931 )

• at 50 weeks

hematopoietic system

increased T cell derived lymphoma incidence ( J:160931 )

• mice develop infiltrating lymphocytes into multiple organs unlike in wild-type mice

• lymphomas consists of enlarged, activated, and highly proliferative T cells

enlarged spleen ( J:160931 )

• at 50 weeks

abnormal T cell activation ( J:160931 )

• lymphomas consists of enlarged, activated, and highly proliferative T cells

increased T cell proliferation ( J:160931 )

• lymphomas consists of enlarged, activated, and highly proliferative T cells

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:160931 )

• mice develop infiltrating lymphocytes into multiple organs unlike in wild-type mice

• lymphomas consists of enlarged, activated, and highly proliferative T cells

cellular

increased T cell proliferation ( J:160931 )

• lymphomas consists of enlarged, activated, and highly proliferative T cells

Genotype
MGI:4460904

cn2

• Allelic Composition: Gt(ROSA)26Sor^{tm1(ITK/SYK)Jrld}/Gt(ROSA)26Sor⁺; Tg(Cd4-cre)1Cwi/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

Enlarged spleen in Gt(ROSA)26Sor^{tm1(ITK/SYK)Jrld}/Gt(ROSA)26Sor⁺ Tg(Cd4-cre)1Cwi/0 mice

mortality/aging

premature death ( J:160931 )

• mice die by 30 weeks

immune system

immune system phenotype ( J:160931 )

N • mice exhibit normal B cell morphology

increased T cell derived lymphoma incidence ( J:160931 )

• mice develop highly proliferative populations of T cells in the bone marrow with infiltration into solid organs, including kidneys, livers, and lungs, unlike in wild-type mice

abnormal T cell differentiation ( J:160931 )

• mice exhibit profound T cell lymphoproliferative disorder unlike wild-type mice

decreased double-positive T cell number ( J:160931 )

decreased T cell number ( J:160931 )

• mice exhibit a decrease in mature peripheral T cells compared with wild-type mice

decreased single-positive T cell number ( J:160931 )

abnormal spleen morphology ( J:160931 )

• at 20 weeks, spleens exhibit infiltration of medium to large-sized lymphoid cells with irregular nuclei, prominent nucleoli, and high mitotic rates suggesting neoplastic growth unlike in wild-type mice

enlarged spleen ( J:160931 )

• at 20 weeks

abnormal T cell activation ( J:160931 )

• the majority of CD4+ and CD8+ T cells exhibit an activated phenotype unlike wild-type cells

increased T cell proliferation ( J:160931 )

• in remaining T cells

neoplasm

increased T cell derived lymphoma incidence ( J:160931 )

• mice develop highly proliferative populations of T cells in the bone marrow with infiltration into solid organs, including kidneys, livers, and lungs, unlike in wild-type mice

behavior/neurological

lethargy ( J:160931 )

• at 12 weeks

hunched posture ( J:160931 )

• at 12 weeks

growth/size/body

cachexia ( J:160931 )

• at 12 weeks

distended abdomen ( J:160931 )

• at 12 weeks

enlarged spleen ( J:160931 )

• at 20 weeks

hematopoietic system

increased T cell derived lymphoma incidence ( J:160931 )

• mice develop highly proliferative populations of T cells in the bone marrow with infiltration into solid organs, including kidneys, livers, and lungs, unlike in wild-type mice

abnormal T cell differentiation ( J:160931 )

• mice exhibit profound T cell lymphoproliferative disorder unlike wild-type mice

decreased T cell number ( J:160931 )

• mice exhibit a decrease in mature peripheral T cells compared with wild-type mice

decreased double-positive T cell number ( J:160931 )

decreased single-positive T cell number ( J:160931 )

abnormal spleen morphology ( J:160931 )

• at 20 weeks, spleens exhibit infiltration of medium to large-sized lymphoid cells with irregular nuclei, prominent nucleoli, and high mitotic rates suggesting neoplastic growth unlike in wild-type mice

enlarged spleen ( J:160931 )

• at 20 weeks

abnormal T cell activation ( J:160931 )

• the majority of CD4+ and CD8+ T cells exhibit an activated phenotype unlike wild-type cells

increased T cell proliferation ( J:160931 )

• in remaining T cells

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:160931 )

• mice develop highly proliferative populations of T cells in the bone marrow with infiltration into solid organs, including kidneys, livers, and lungs, unlike in wild-type mice

cellular

increased T cell proliferation ( J:160931 )

• in remaining T cells