Phenotypes associated with this allele

• Allele Symbol: Msh2^tm2.2Rak
• Allele Name: targeted mutation 2.2, Raju Kucherlapati
• Allele ID: MGI:4460263
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Msh2^tm2.2Rak/Msh2^tm2.2Rak	involves: 129/Sv * C57BL/6 * FVB/N * SJL	MGI:4460269

Genotype
MGI:4460269

hm1

• Allelic Composition: Msh2^tm2.2Rak/Msh2^tm2.2Rak
• Genetic Background: involves: 129/Sv * C57BL/6 * FVB/N * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:161577 )

• median survival is 6 months and all mice die by 11 months

neoplasm

increased gastrointestinal tumor incidence ( J:161577 )

• 33% of mice develop small intestine tumors unlike wild-type mice

increased lymphoma incidence ( J:161577 )

• in 67% of mice

homeostasis/metabolism

impaired mismatch repair ( J:161577 )

• mouse embryonic fibroblast extracts fail to exhibit mismatch repair unlike extracts from wild-type cells

• however, mismatch repair is rescued by the addition of cellular extract from Exo1^tm1Wed homozygotes

cellular

impaired mismatch repair ( J:161577 )

• mouse embryonic fibroblast extracts fail to exhibit mismatch repair unlike extracts from wild-type cells

• however, mismatch repair is rescued by the addition of cellular extract from Exo1^tm1Wed homozygotes

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:161577 )

• 33% of mice develop small intestine tumors unlike wild-type mice