Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Exo1tm1Wed
Name:	exonuclease 1; targeted mutation 1, Winfried Edelmann
MGI ID:	MGI:2653925
Synonyms:	Exo1-, Exo1mut
Gene:	Exo1  Location: Chr1:175708334-175738962 bp, + strand  Genetic Position: Chr1, 81.9 cM
Alliance:	Exo1tm1Wed page

Germline Transmission:	Earliest citation of germline transmission: J:82426
Parent Cell Line:	WW6 (ES Cell)
Strain of Origin:	STOCK 129/Sv and C57BL/6J and SJL

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A hygromycin resistance gene cassette was inserted into exon 6 via homologous recombination resulting in disruption of the I-nuclease domain. Disruption of exon 6 in homozygous mutant ES cells was confirmed by northern and Western blot analysis. (J:82426)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

List all tumor models in MMHCdb carrying Exo1tm1Wed

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Exo1 Mutation:	45 strains or lines available

Original:	J:82426 Wei K, et al., Inactivation of Exonuclease 1 in mice results in DNA mismatch repair defects, increased cancer susceptibility, and male and female sterility. Genes Dev. 2003 Mar 1;17(5):603-14
All:	14 reference(s)