All Phenotypes Hif1an<tm1.1Rsjo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Hif1an^tm1.1Rsjo
targeted mutation 1.1, Randall S Johnson
MGI:4459908

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Hif1an^tm1.1Rsjo/Hif1an^tm1.1Rsjo Tg(Nes-cre)1Wme/0	involves: 129 * C57BL/6 * CBA	MGI:4459909
cn2	Hif1an^tm1.1Rsjo/Hif1an^tm1.1Rsjo Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺	involves: 129 * C57BL/6 * DBA	MGI:4459910

Allelic Composition	Hif1an^tm1.1Rsjo/Hif1an^tm1.1Rsjo Tg(Nes-cre)1Wme/0
Genetic Background	involves: 129 * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1an^tm1.1Rsjo mutation (0 available); any Hif1an mutation (20 available)
Tg(Nes-cre)1Wme mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased circulating insulin level ( J:160941 )

• decreased fasting plasma insulin levels

increased insulin sensitivity ( J:160941 )

growth/size/body

decreased susceptibility to weight gain ( J:160941 )

• at 8 week and 10 week time points mice fed 60% fat diet gain significantly less weight

Allelic Composition	Hif1an^tm1.1Rsjo/Hif1an^tm1.1Rsjo Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
Genetic Background	involves: 129 * C57BL/6 * DBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hif1an^tm1.1Rsjo mutation (0 available); any Hif1an mutation (20 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:160941 )

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