Phenotypes associated with this allele

• Allele Symbol: Pknox1^tm1Ngc
• Allele Name: targeted mutation 1, Neal G Copeland
• Allele ID: MGI:4459452
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pknox1^tm1Ngc/Pknox1^tm1Ngc	Not Specified	MGI:4460923
cx2	Pknox1^tm1Ngc/Pknox1^+ Tg(IghMyc)22Bri/0	involves: C57BL * SJL	MGI:5469883

Genotype
MGI:4460923

hm1

• Allelic Composition: Pknox1^tm1Ngc/Pknox1^tm1Ngc
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:111418 )

• mice exhibit embryonic lethality at E7.5

Genotype
MGI:5469883

cx2

• Allelic Composition: Pknox1^tm1Ngc/Pknox1⁺; Tg(IghMyc)22Bri/0
• Genetic Background: involves: C57BL * SJL

Pro-B tumor in Pknox1^tm1Ngc/Pknox1⁺ Tg(IghMyc)22Bri/0 mice

mortality/aging

premature death ( J:192251 )

• median survival time is 23 weeks compared with 58 weeks for Tg(IghMyc)22Bri mice

immune system

decreased B cell apoptosis ( J:192251 )

• in the spleen

increased B cell proliferation ( J:192251 )

• in the spleen

neoplasm

increased B cell derived lymphoma incidence ( J:192251 )

• accelerated and enhanced immature B cell lymphomas compared with Tg(IghMyc)22Bri mice

cellular

decreased B cell apoptosis ( J:192251 )

• in the spleen

increased B cell proliferation ( J:192251 )

• in the spleen

hematopoietic system

decreased B cell apoptosis ( J:192251 )

• in the spleen

increased B cell proliferation ( J:192251 )

• in the spleen