About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Il13tm1(YFP/cre)Lky
targeted mutation 1, Richard M Locksley
MGI:4459318
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
Il13tm1(YFP/cre)Lky/Il13tm1(YFP/cre)Lky 		involves: 129P2/OlaHsd * 129S4/SvJae MGI:5435902
cn2
 		Il13tm1(YFP/cre)Lky/Il13+
Il4tm1(CD2)Mmrs/Il4+
Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+ 		involves: 129P2/OlaHsd * 129S4/SvJae MGI:5435903
cn3
 		Gata3tm1Iho/Gata3tm1Iho
Il13tm1(YFP/cre)Lky/Il13+ 		involves: 129S4/SvJae MGI:5435904


Genotype
MGI:5435902
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
Il13tm1(YFP/cre)Lky/Il13tm1(YFP/cre)Lky
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Lky mutation (3 available); any Gt(ROSA)26Sor mutation (942 available)
Il13tm1(YFP/cre)Lky mutation (1 available); any Il13 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased eosinophil cell number ( J:178986 )
• in the lungs of mice infected with N. brasiliensis
decreased IgG1 level ( J:178986 )
• slightly less in an anti-NP response
decreased interleukin-13 secretion ( J:178986 )
• in lung CD4+ T cells of mice infected with N. brasiliensis
decreased interleukin-5 secretion ( J:178986 )
• in lung CD4+ T cells of mice infected with N. brasiliensis
increased susceptibility to parasitic infection ( J:178986 )
• mice fail to expel the helminth Nippostrongylus brasiliensis

hematopoietic system
decreased eosinophil cell number ( J:178986 )
• in the lungs of mice infected with N. brasiliensis
decreased IgG1 level ( J:178986 )
• slightly less in an anti-NP response




Genotype
MGI:5435903
cn2
Allelic
Composition		 Il13tm1(YFP/cre)Lky/Il13+
Il4tm1(CD2)Mmrs/Il4+
Gt(ROSA)26Sortm1(DTA)Lky/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Lky mutation (3 available); any Gt(ROSA)26Sor mutation (942 available)
Il13tm1(YFP/cre)Lky mutation (1 available); any Il13 mutation (29 available)
Il4tm1(CD2)Mmrs mutation (0 available); any Il4 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased eosinophil cell number ( J:178986 )
• in the lungs of mice infected with N. brasiliensis
increased susceptibility to parasitic infection ( J:178986 )
• mice exhibit reduced helminthes Nippostrongylus brasiliensis expulsion compared with control mice

hematopoietic system
decreased eosinophil cell number ( J:178986 )
• in the lungs of mice infected with N. brasiliensis




Genotype
MGI:5435904
cn3
Allelic
Composition		 Gata3tm1Iho/Gata3tm1Iho
Il13tm1(YFP/cre)Lky/Il13+
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gata3tm1Iho mutation (0 available); any Gata3 mutation (31 available)
Il13tm1(YFP/cre)Lky mutation (1 available); any Il13 mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased eosinophil cell number ( J:178986 )
• in the lungs of mice infected with N. brasiliensis
increased susceptibility to parasitic infection ( J:178986 )
• mice exhibit reduced helminth Nippostrongylus brasiliensis expulsion compared with control mice

hematopoietic system
decreased eosinophil cell number ( J:178986 )
• in the lungs of mice infected with N. brasiliensis




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory