Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1tm1Sakh mutation
(0 available);
any
Esr1 mutation
(67 available)
Tg(MMTV-cre)4Mam mutation
(1 available)
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endocrine/exocrine glands
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• mammary ductal outgrowth arrested at prepubertal stage
• little ductal invasion of fat pad at 6 months
• minimal side branching
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integument
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• mammary ductal outgrowth arrested at prepubertal stage
• little ductal invasion of fat pad at 6 months
• minimal side branching
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1tm1Sakh mutation
(0 available);
any
Esr1 mutation
(67 available)
Tg(Wap-cre)11738Mam mutation
(3 available)
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endocrine/exocrine glands
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• mosaic mammary gland phenotype in the first lactation
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• mild defect in tertiary branching during first lactation
• aberrantly dilated ducts with few side branches during second lactation
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• some normal sized alveoli in first lactation
• regions of reduced growth in the first lactation
• fewer lobular alveoli during second lactation
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• one third of first lactation pups are malnurished with body weights 17% less than controls at 21 days
• more severe growth retardation in second lactation pups with body weights 50% of controls at 6 days
• normal milk quality
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integument
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• mosaic mammary gland phenotype in the first lactation
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|
|
• mild defect in tertiary branching during first lactation
• aberrantly dilated ducts with few side branches during second lactation
|
|
|
• some normal sized alveoli in first lactation
• regions of reduced growth in the first lactation
• fewer lobular alveoli during second lactation
|
|
|
• one third of first lactation pups are malnurished with body weights 17% less than controls at 21 days
• more severe growth retardation in second lactation pups with body weights 50% of controls at 6 days
• normal milk quality
|
Analysis Tools