All Phenotypes Pold1<tm1.1Bdp> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pold1^tm1.1Bdp/Pold1^tm1.1Bdp	B6.129-Pold1^tm1.1Bdp	MGI:4366920
cx2	Pold1^tm1.1Bdp/Pold1^tm1.1Bdp Pole^tm1.1Bdp/Pole^tm1.1Bdp	B6.129-Pole^tm1.1Bdp Pold1^tm1.1Bdp	MGI:4366922
cx3	Mlh1^tm1Rak/Mlh1^tm1Rak Pold1^tm1.1Bdp/Pold1^tm1.1Bdp	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J	MGI:4366923
cx4	Msh2^tm1Rak/Msh2^tm1Rak Pold1^tm1.1Bdp/Pold1^tm1.1Bdp	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J	MGI:4366926

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:153684 )

• mice die before 15 months

neoplasm

increased intestinal adenocarcinoma incidence ( J:153684 )

• 14% of mice develop intestinal adenomas and adenocarcinomas compared with 5% of wild-type mice

increased intestinal adenoma incidence ( J:153684 )

• 14% of mice develop intestinal adenomas and adenocarcinomas compared with 5% of wild-type mice

increased skin tumor incidence ( J:153684 )

• 25% of mice develop tail skin squamous cell neoplasms (papilloma or carcinoma) unlike wild-type mice

increased lymphoma incidence ( J:153684 )

• 14% of mice develop nodal lymphomas compared with 6% of wild-type mice

increased T cell derived lymphoma incidence ( J:153684 )

• in 42% of mice unlike wild-type mice

increased lung tumor incidence ( J:153684 )

• 28% of mice develop lung adenomas and adenocarcinomas compared with 9% of wild-type mice

integument

increased skin tumor incidence ( J:153684 )

• 25% of mice develop tail skin squamous cell neoplasms (papilloma or carcinoma) unlike wild-type mice

digestive/alimentary system

increased intestinal adenocarcinoma incidence ( J:153684 )

• 14% of mice develop intestinal adenomas and adenocarcinomas compared with 5% of wild-type mice

increased intestinal adenoma incidence ( J:153684 )

• 14% of mice develop intestinal adenomas and adenocarcinomas compared with 5% of wild-type mice

respiratory system

increased lung tumor incidence ( J:153684 )

• 28% of mice develop lung adenomas and adenocarcinomas compared with 9% of wild-type mice

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:153684 )

• in 42% of mice unlike wild-type mice

Allelic Composition	Pold1^tm1.1Bdp/Pold1^tm1.1Bdp Pole^tm1.1Bdp/Pole^tm1.1Bdp
Genetic Background	B6.129-Pole^tm1.1Bdp Pold1^tm1.1Bdp

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pold1^tm1.1Bdp mutation (0 available); any Pold1 mutation (62 available)
Pole^tm1.1Bdp mutation (0 available); any Pole mutation (99 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:153684 )

• mice die before 6 months

neoplasm

increased T cell derived lymphoma incidence ( J:153684 )

• in 82% of mice unlike in wild-type mice

increased skin tumor incidence ( J:153684 )

• 6% of mice develop tail skin squamous cell neoplasms (papilloma or carcinoma) unlike wild-type mice

integument

increased skin tumor incidence ( J:153684 )

• 6% of mice develop tail skin squamous cell neoplasms (papilloma or carcinoma) unlike wild-type mice

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:153684 )

• in 82% of mice unlike in wild-type mice

Allelic Composition	Mlh1^tm1Rak/Mlh1^tm1Rak Pold1^tm1.1Bdp/Pold1^tm1.1Bdp
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mlh1^tm1Rak mutation (1 available); any Mlh1 mutation (42 available)
Pold1^tm1.1Bdp mutation (0 available); any Pold1 mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:153684 )

• mice do not survive beyond E9.5

Allelic Composition	Msh2^tm1Rak/Msh2^tm1Rak Pold1^tm1.1Bdp/Pold1^tm1.1Bdp
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msh2^tm1Rak mutation (1 available); any Msh2 mutation (95 available)
Pold1^tm1.1Bdp mutation (0 available); any Pold1 mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:153684 )

• no mice are present at weaning

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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