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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fbxl5L5Jcs32
lethal 5 John C Schimenti 32
MGI:4458019
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fbxl5L5Jcs32/Fbxl5L5Jcs32 involves: C3HeB/FeJ * C57BL/6J MGI:4458021


Genotype
MGI:4458021
hm1
Allelic
Composition		 Fbxl5L5Jcs32/Fbxl5L5Jcs32
Genetic
Background		 involves: C3HeB/FeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbxl5L5Jcs32 mutation (1 available); any Fbxl5 mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality, complete penetrance ( J:100332 )
• lethality occurs midgestation, between E8.5 to E12.5

embryo
open neural tube ( J:100332 )
• homzygotes exhibit a failure of the anterior neural tube closure

nervous system
open neural tube ( J:100332 )
• homzygotes exhibit a failure of the anterior neural tube closure

cardiovascular system

homeostasis/metabolism




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory