About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Portm3Ding
targeted mutation 3, Xinxin Ding
MGI:4457492
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Portm3Ding/Portm3Ding C57BL/6-Portm3Ding MGI:4457493
hm2
 		Portm3Ding/Portm3Ding involves: C57BL/6 * DBA MGI:4457495
cn3
 		Portm3Ding/Portm3Ding
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: C57BL/6 * DBA MGI:4457494


Genotype
MGI:4457493
hm1
Allelic
Composition		 Portm3Ding/Portm3Ding
Genetic
Background		 C57BL/6-Portm3Ding
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Portm3Ding mutation (1 available); any Por mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:159168 )
N
• male mice are fertile

homeostasis/metabolism

behavior/neurological
enhanced behavioral response to anesthetic ( J:159168 )
• pentobarbital-treated mice exhibit extended sleeping time compared with similarly treated wild-type mice

growth/size/body
decreased body weight ( J:159168 )
• in male and female mice

cardiovascular system
decreased heart weight ( J:159168 )
• in male mice

renal/urinary system
decreased kidney weight ( J:159168 )
• in male mice

respiratory system
decreased lung weight ( J:159168 )
• in male mice




Genotype
MGI:4457495
hm2
Allelic
Composition		 Portm3Ding/Portm3Ding
Genetic
Background		 involves: C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Portm3Ding mutation (1 available); any Por mutation (80 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:159168 )
• fewer than expected mice are produced (no time point given)




Genotype
MGI:4457494
cn3
Allelic
Composition		 Portm3Ding/Portm3Ding
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Portm3Ding mutation (1 available); any Por mutation (80 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:159168 )
N
• mice exhibit normal embryonic survival

reproductive system

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:159168 )
N
• mice exhibit normal circulating cholesterol levels
abnormal enzyme/coenzyme activity ( J:159168 )
• NNK-treated mice exhibit reduced levels of DNA adduction (a measure of NKK activation) compared with similarly treated wild-type mice

behavior/neurological
behavior/neurological phenotype ( J:159168 )
N
• mice exhibit normal sleeping time in response to pentobarbital treatment

growth/size/body
growth/size/body region phenotype ( J:159168 )
N
• mice exhibit normal body and organ weights




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory