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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gdnftm1.1Neas
targeted mutation 1.1, Neil A Shneider
MGI:4456155
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gdnftm1.1Neas/Gdnftm1.1Neas
Myf5tm3(cre)Sor/Myf5+ 		involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * SJL MGI:4456171
cn2
 		Gdnftm1.1Neas/Gdnftm1.1Neas
Egr3tm1(cre)Mod/Egr3tm1(cre)Mod 		involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL MGI:4456169
cn3
 		Gdnftm1Bbd/Gdnftm1.1Neas
Egr3tm1(cre)Mod/Egr3+ 		involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL MGI:4456170


Genotype
MGI:4456171
cn1
Allelic
Composition		 Gdnftm1.1Neas/Gdnftm1.1Neas
Myf5tm3(cre)Sor/Myf5+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gdnftm1.1Neas mutation (1 available); any Gdnf mutation (18 available)
Myf5tm3(cre)Sor mutation (1 available); any Myf5 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cholinergic neuron morphology ( J:160727 )
• at P20, mice exhibit a loss of small diameter cholinergic motor neurons compared with wild-type mice
decreased motor neuron number ( J:160727 )
• at P20, mice exhibit a loss of small diameter cholinergic motor neurons compared with wild-type mice




Genotype
MGI:4456169
cn2
Allelic
Composition		 Gdnftm1.1Neas/Gdnftm1.1Neas
Egr3tm1(cre)Mod/Egr3tm1(cre)Mod
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr3tm1(cre)Mod mutation (0 available); any Egr3 mutation (15 available)
Gdnftm1.1Neas mutation (1 available); any Gdnf mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cholinergic neuron morphology ( J:160727 )
• at P20, mice exhibit a decrease in small cholinergic motor neurons compared with wild-type mice
decreased motor neuron number ( J:160727 )
• at P20, mice exhibit a decrease in small cholinergic motor neurons compared with wild-type mice
• mice exhibit a depletion in gamma-motor neurons at a similar time course as observed in Egr3tm1Jmi homozygotes

muscle
muscle phenotype ( J:160727 )
N
• mice exhibit normal muscle spindle morphology




Genotype
MGI:4456170
cn3
Allelic
Composition		 Gdnftm1Bbd/Gdnftm1.1Neas
Egr3tm1(cre)Mod/Egr3+
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * C57BL/6J * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr3tm1(cre)Mod mutation (0 available); any Egr3 mutation (15 available)
Gdnftm1.1Neas mutation (1 available); any Gdnf mutation (18 available)
Gdnftm1Bbd mutation (0 available); any Gdnf mutation (18 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal cholinergic neuron morphology ( J:160727 )
• at P20, mice exhibit a decrease in small cholinergic motor neurons compared with wild-type mice
decreased motor neuron number ( J:160727 )
• at P20, mice exhibit a decrease in small cholinergic motor neurons compared with wild-type mice
• mice exhibit selective loss of gamma-motor neurons compared with wild-type mice




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory