Egr3^tm1(cre)Mod
Targeted Allele Detail

Summary

• Symbol: Egr3^tm1(cre)Mod
• Name: early growth response 3; targeted mutation 1, Michael J O'Donovan
• MGI ID: MGI:3843775
• Synonyms: Egr3CRE, Egr3^CRE
• Gene: Egr3 Location: Chr14:70314766-70320062 bp, + strand Genetic Position: Chr14, 36.2 cM, cytoband D1
• Alliance: Egr3^tm1(cre)Mod page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147957
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutation: Insertion
• Egr3^tm1(cre)Mod expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Egr3 (MGI:1306780)

• Mutation details: The targeting construct was designed to insert an IRES-Cre-pA cassette in the 3' UTR of the Egr3 gene. Electroporation of the targeting vector into W9.5 ES cells. Clones were analyzed for homologous recombination, and positive clones were injected into C57BL/6 blastocysts to generate chimeric founders. This allele preserves expression of the endogenous Egr3 gene and expresses cre under control of the Egr3 promoter. (J:147957)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Egr3 (mouse) Summary of all recombinase alleles driven by Egr3. Alliance mouse Egr3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Egr3 Mutation: 15 strains or lines available

References

• Original: J:147957 Shneider NA, et al., Functionally reduced sensorimotor connections form with normal specificity despite abnormal muscle spindle development: the role of spindle-derived neurotrophin 3. J Neurosci. 2009 Apr 15;29(15):4719-35
• All: 3 reference(s)