Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr3tm1(cre)Mod mutation
(0 available);
any
Egr3 mutation
(15 available)
Ntf3tm2Jae mutation
(1 available);
any
Ntf3 mutation
(24 available)
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behavior/neurological
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• mice show a flexed posture when inverted, similar to Erbb2 conditional mutants
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• mice exhibit a wide-based, ataxic gait, similar to Erbb2 conditional mutants; onset of abnormalities is delayed and is less pronounced, however, relative to Erbb2 conditional animals
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nervous system
N |
• functional specificity of connections between afferents and motor neurons is preserved in conditional mutants
• anatomical specificity of connections between muscle afferents projecting to agonistic and antagonistic motor neurons is preserved in conditional mutants
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• at P5, ventral root potentials are normal, but by P14, amplitudes of potentials are reduced by >80% compared to controls
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr3tm1(cre)Mod mutation
(0 available);
any
Egr3 mutation
(15 available)
Gdnftm1.1Neas mutation
(1 available);
any
Gdnf mutation
(18 available)
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nervous system
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• at P20, mice exhibit a decrease in small cholinergic motor neurons compared with wild-type mice
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• at P20, mice exhibit a decrease in small cholinergic motor neurons compared with wild-type mice
• mice exhibit a depletion in gamma-motor neurons at a similar time course as observed in Egr3tm1Jmi homozygotes
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muscle
N |
• mice exhibit normal muscle spindle morphology
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Egr3tm1(cre)Mod mutation
(0 available);
any
Egr3 mutation
(15 available)
Gdnftm1.1Neas mutation
(1 available);
any
Gdnf mutation
(18 available)
Gdnftm1Bbd mutation
(0 available);
any
Gdnf mutation
(18 available)
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nervous system
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• at P20, mice exhibit a decrease in small cholinergic motor neurons compared with wild-type mice
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• at P20, mice exhibit a decrease in small cholinergic motor neurons compared with wild-type mice
• mice exhibit selective loss of gamma-motor neurons compared with wild-type mice
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