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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Foxn1tm1.1Dmsu
targeted mutation 1.1, Dong-Ming Su
MGI:4454641
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu involves: 129/Sv * C57BL/6 * SJL MGI:4454656
cn2
 		Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129/Sv * C57BL/6 * CBA * SJL MGI:4454657
cn3
 		Foxn1nu/Foxn1tm1.1Dmsu
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129/Sv * C57BL/6 * CBA * SJL MGI:4454658
cn4
 		Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu
Tg(KRT18-cre/ERT2)1Rgo/0 		involves: 129/Sv * C57BL/6 * FVB/N * SJL MGI:4454660
cn5
 		Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu
Tg(KRT5-cre/ERT2)2Ipc/0 		involves: 129/Sv * C57BL/6 * SJL MGI:4454659


Genotype
MGI:4454656
hm1
Allelic
Composition		 Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1tm1.1Dmsu mutation (1 available); any Foxn1 mutation (106 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:159773 )
• mice are normal




Genotype
MGI:4454657
cn2
Allelic
Composition		 Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1tm1.1Dmsu mutation (1 available); any Foxn1 mutation (106 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Thymic atrophy in tamoxifen treated Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu Tg(KRT5-cre/ERT2)2Ipc/0 mice and Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu Tg(CAG-cre/Esr1*)5Amc/0 mice

immune system
abnormal thymus morphology ( J:159773 )
• following tamoxifen treatment, mice exhibit a decrease in thymic stromal cells compared to in wild-type mice
small thymus ( J:159773 )
• following tamoxifen treatment
thymus atrophy ( J:159773 )
• following tamoxifen treatment
decreased thymocyte number ( J:159773 )
• following tamoxifen treatment
decreased double-positive T cell number ( J:159773 )
• following tamoxifen treatment

hematopoietic system
abnormal thymus morphology ( J:159773 )
• following tamoxifen treatment, mice exhibit a decrease in thymic stromal cells compared to in wild-type mice
small thymus ( J:159773 )
• following tamoxifen treatment
thymus atrophy ( J:159773 )
• following tamoxifen treatment
decreased thymocyte number ( J:159773 )
• following tamoxifen treatment
decreased double-positive T cell number ( J:159773 )
• following tamoxifen treatment

endocrine/exocrine glands
abnormal thymus morphology ( J:159773 )
• following tamoxifen treatment, mice exhibit a decrease in thymic stromal cells compared to in wild-type mice
small thymus ( J:159773 )
• following tamoxifen treatment
thymus atrophy ( J:159773 )
• following tamoxifen treatment
decreased thymocyte number ( J:159773 )
• following tamoxifen treatment




Genotype
MGI:4454658
cn3
Allelic
Composition		 Foxn1nu/Foxn1tm1.1Dmsu
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1nu mutation (43 available); any Foxn1 mutation (106 available)
Foxn1tm1.1Dmsu mutation (1 available); any Foxn1 mutation (106 available)
Tg(CAG-cre/Esr1*)5Amc mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased thymocyte apoptosis ( J:159773 )
• following tamoxifen treatment, mature medullary thymic epithelial cells undergo increased apoptosis compared to in wild-type mice
abnormal thymus epithelium morphology ( J:159773 )
• following tamoxifen treatment, medullary thymic epithelial cells are reduced compared to in wild-type mice
• mature medullary thymic epithelial cells are more affected than presumptive medullary thymic epithelial cell precursors following tamoxifen treatment
• however, cortical thymic epithelial cells are not significantly reduced following tamoxifen treatment
decreased thymocyte number ( J:159773 )
• following tamoxifen treatment

hematopoietic system
increased thymocyte apoptosis ( J:159773 )
• following tamoxifen treatment, mature medullary thymic epithelial cells undergo increased apoptosis compared to in wild-type mice
abnormal thymus epithelium morphology ( J:159773 )
• following tamoxifen treatment, medullary thymic epithelial cells are reduced compared to in wild-type mice
• mature medullary thymic epithelial cells are more affected than presumptive medullary thymic epithelial cell precursors following tamoxifen treatment
• however, cortical thymic epithelial cells are not significantly reduced following tamoxifen treatment
decreased thymocyte number ( J:159773 )
• following tamoxifen treatment

cellular
increased thymocyte apoptosis ( J:159773 )
• following tamoxifen treatment, mature medullary thymic epithelial cells undergo increased apoptosis compared to in wild-type mice

endocrine/exocrine glands
increased thymocyte apoptosis ( J:159773 )
• following tamoxifen treatment, mature medullary thymic epithelial cells undergo increased apoptosis compared to in wild-type mice
abnormal thymus epithelium morphology ( J:159773 )
• following tamoxifen treatment, medullary thymic epithelial cells are reduced compared to in wild-type mice
• mature medullary thymic epithelial cells are more affected than presumptive medullary thymic epithelial cell precursors following tamoxifen treatment
• however, cortical thymic epithelial cells are not significantly reduced following tamoxifen treatment
decreased thymocyte number ( J:159773 )
• following tamoxifen treatment




Genotype
MGI:4454660
cn4
Allelic
Composition		 Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu
Tg(KRT18-cre/ERT2)1Rgo/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1tm1.1Dmsu mutation (1 available); any Foxn1 mutation (106 available)
Tg(KRT18-cre/ERT2)1Rgo mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:159773 )
N
• following tamoxifen treatment, mice exhibit normal thymus size, profile of CD4 versus CD8 cells, thymic epithelial cell numbers, and thymic architecture




Genotype
MGI:4454659
cn5
Allelic
Composition		 Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu
Tg(KRT5-cre/ERT2)2Ipc/0
Genetic
Background		 involves: 129/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxn1tm1.1Dmsu mutation (1 available); any Foxn1 mutation (106 available)
Tg(KRT5-cre/ERT2)2Ipc mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Thymic atrophy in tamoxifen treated Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu Tg(KRT5-cre/ERT2)2Ipc/0 mice and Foxn1tm1.1Dmsu/Foxn1tm1.1Dmsu Tg(CAG-cre/Esr1*)5Amc/0 mice

immune system
abnormal thymus corticomedullary boundary morphology ( J:159773 )
• following tamoxifen treatment, the medullary region architecture is altered and the corticomedullary junction becomes indistinct compared to in wild-type mice
abnormal thymus medulla morphology ( J:159773 )
• following tamoxifen treatment, the medullary region architecture is altered and the corticomedullary junction becomes indistinct compared to in wild-type mice
small thymus ( J:159773 )
• following tamoxifen treatment
thymus atrophy ( J:159773 )
• following tamoxifen treatment
decreased thymocyte number ( J:159773 )
• following tamoxifen treatment

hematopoietic system
abnormal thymus corticomedullary boundary morphology ( J:159773 )
• following tamoxifen treatment, the medullary region architecture is altered and the corticomedullary junction becomes indistinct compared to in wild-type mice
abnormal thymus medulla morphology ( J:159773 )
• following tamoxifen treatment, the medullary region architecture is altered and the corticomedullary junction becomes indistinct compared to in wild-type mice
small thymus ( J:159773 )
• following tamoxifen treatment
thymus atrophy ( J:159773 )
• following tamoxifen treatment
decreased thymocyte number ( J:159773 )
• following tamoxifen treatment

endocrine/exocrine glands
abnormal thymus corticomedullary boundary morphology ( J:159773 )
• following tamoxifen treatment, the medullary region architecture is altered and the corticomedullary junction becomes indistinct compared to in wild-type mice
abnormal thymus medulla morphology ( J:159773 )
• following tamoxifen treatment, the medullary region architecture is altered and the corticomedullary junction becomes indistinct compared to in wild-type mice
small thymus ( J:159773 )
• following tamoxifen treatment
thymus atrophy ( J:159773 )
• following tamoxifen treatment
decreased thymocyte number ( J:159773 )
• following tamoxifen treatment




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory