All Phenotypes Patz1<tm1.1Welm> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Patz1^tm1.1Welm
targeted mutation 1.1, Wilfried Ellmeier
MGI:4454313

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Patz1^tm1.1Welm/Patz1^tm1.1Welm	involves: 129P2/OlaHsd	MGI:4454314
hm2	Patz1^tm1.1Welm/Patz1^tm1.1Welm	involves: 129P2/OlaHsd * C57BL/6	MGI:4454317
cx3	Rr100^tm2.1Welm/Rr100^tm2.1Welm Patz1^tm1.1Welm/Patz1^tm1.1Welm	involves: 129P2/OlaHsd * C57BL/6	MGI:4454318
cx4	Patz1^tm1.1Welm/Patz1^tm1.1Welm Tg(TcraTcrb)1100Mjb/0	involves: 129P2/OlaHsd * C57BL/6	MGI:4454321
cx5	Patz1^tm1.1Welm/Patz1^tm1.1Welm Tg(TcraTcrb)425Cbn/0	involves: C57BL/6	MGI:4454319

Allelic Composition	Patz1^tm1.1Welm/Patz1^tm1.1Welm
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Patz1^tm1.1Welm mutation (0 available); any Patz1 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality, incomplete penetrance ( J:158947 )

• born at a lower than expected Mendelian frequency

growth/size/body

decreased body size ( J:158947 )

decreased body weight ( J:158947 )

hematopoietic system

decreased thymocyte number ( J:158947 )

• 40% lower thymocyte numbers

abnormal T cell subpopulation ratio ( J:158947 )

• increase in the ratios of CD4SP thymocytes to CD8SP thymocytes and of CD4+ to CD8+CD3+ lymph node T cells

decreased splenocyte number ( J:158947 )

• 50% lower splenocyte numbers

immune system

decreased thymocyte number ( J:158947 )

• 40% lower thymocyte numbers

abnormal T cell subpopulation ratio ( J:158947 )

• increase in the ratios of CD4SP thymocytes to CD8SP thymocytes and of CD4+ to CD8+CD3+ lymph node T cells

decreased splenocyte number ( J:158947 )

• 50% lower splenocyte numbers

endocrine/exocrine glands

decreased thymocyte number ( J:158947 )

• 40% lower thymocyte numbers

Allelic Composition	Patz1^tm1.1Welm/Patz1^tm1.1Welm
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Patz1^tm1.1Welm mutation (0 available); any Patz1 mutation (55 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

prenatal lethality ( J:158947 )

• viability is much lower when mice are backcrossed onto a C57BL/6 background

Allelic Composition	Rr100^tm2.1Welm/Rr100^tm2.1Welm Patz1^tm1.1Welm/Patz1^tm1.1Welm
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Patz1^tm1.1Welm mutation (0 available); any Patz1 mutation (55 available)
Rr100^tm2.1Welm mutation (0 available); any Rr100 mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:158947 )

N	• unlike mice with a wild-type copy of Patz, null mice have no defects in T cell differentiation

Allelic Composition	Patz1^tm1.1Welm/Patz1^tm1.1Welm Tg(TcraTcrb)1100Mjb/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Patz1^tm1.1Welm mutation (0 available); any Patz1 mutation (55 available)
Tg(TcraTcrb)1100Mjb mutation (6 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T cell subpopulation ratio ( J:158947 )

• include a much higher percentage of CD4 SP cells and a correspondingly smaller CD8 SP population

increased CD4-positive, alpha-beta T cell number ( J:158947 )

decreased CD8-positive, alpha-beta T cell number ( J:158947 )

immune system

abnormal T cell subpopulation ratio ( J:158947 )

• include a much higher percentage of CD4 SP cells and a correspondingly smaller CD8 SP population

increased CD4-positive, alpha-beta T cell number ( J:158947 )

decreased CD8-positive, alpha-beta T cell number ( J:158947 )

Allelic Composition	Patz1^tm1.1Welm/Patz1^tm1.1Welm Tg(TcraTcrb)425Cbn/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Patz1^tm1.1Welm mutation (0 available); any Patz1 mutation (55 available)
Tg(TcraTcrb)425Cbn mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal T cell subpopulation ratio ( J:158947 )

• slightly higher percentage of CD4+ T cells and correspondingly lower frequency of CD8+ T

increased CD4-positive, alpha-beta T cell number ( J:158947 )

decreased CD8-positive, alpha-beta T cell number ( J:158947 )

immune system

abnormal T cell subpopulation ratio ( J:158947 )

• slightly higher percentage of CD4+ T cells and correspondingly lower frequency of CD8+ T

increased CD4-positive, alpha-beta T cell number ( J:158947 )

decreased CD8-positive, alpha-beta T cell number ( J:158947 )

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