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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ightm4.1Mnz
targeted mutation 4.1, Michel C Nussenzweig
MGI:4452369
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Ightm3Mnz/Ightm4.1Mnz involves: C57BL/6 MGI:4452375
cn2
 		Aicdatm1Hon/Aicdatm1Hon
Ightm3Mnz/Ightm4.1Mnz
Trp53bp1tm1Jc/Trp53bp1tm1Jc 		involves: 129 * C57BL/6 * CBA MGI:4452376
cx3
 		Aicdatm1Hon/Aicdatm1Hon
Ightm4.1Mnz/Igh+
Trp53bp1tm1Jc/Trp53bp1tm1Jc 		involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj MGI:5484523
cx4
 		Aicdatm1Hon/Aicdatm1Hon
Exo1tm1Wed/Exo1tm1Wed
Ightm4.1Mnz/Igh+
Trp53bp1tm1Jc/Trp53bp1tm1Jc 		involves: 129 * C57BL/6 * CBA/JNCrlj * SJL MGI:5484525
cx5
 		Aicdatm1Hon/Aicdatm1Hon
Blmtm3Brd/Blmtm3Brd
Ightm4.1Mnz/Igh+
Trp53bp1tm1Jc/Trp53bp1tm1Jc 		involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj MGI:5484527
cx6
 		Aicdatm1Hon/Aicdatm1Hon
Ightm4.1Mnz/Igh+ 		involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj MGI:5484524
cx7
 		Aicdatm1Hon/Aicdatm1Hon
Exo1tm1Wed/Exo1tm1Wed
Ightm4.1Mnz/Igh+ 		involves: C57BL/6 * CBA/JNCrlj * SJL MGI:5484526


Genotype
MGI:4452375
ht1
Allelic
Composition		 Ightm3Mnz/Ightm4.1Mnz
Genetic
Background		 involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm3Mnz mutation (1 available); any Igh mutation (43 available)
Ightm4.1Mnz mutation (0 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:159173 )
N
• mice exhibit normal B cell development and class switch recombination to IgG1 following stimulation with LPS and IL4




Genotype
MGI:4452376
cn2
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Ightm3Mnz/Ightm4.1Mnz
Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic
Background		 involves: 129 * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (55 available)
Ightm3Mnz mutation (1 available); any Igh mutation (43 available)
Ightm4.1Mnz mutation (0 available); any Igh mutation (43 available)
Trp53bp1tm1Jc mutation (1 available); any Trp53bp1 mutation (100 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
abnormal class switch recombination ( J:159173 )
• I-SceI mediated class switch recombination in LPS- and IL4-stimulated B cells is decreased compared to similarly treated Aicdatm1Hon/Aicdatm1Hon Ightm3Mnz/Ightm4.1Mnz B cells

immune system
abnormal class switch recombination ( J:159173 )
• I-SceI mediated class switch recombination in LPS- and IL4-stimulated B cells is decreased compared to similarly treated Aicdatm1Hon/Aicdatm1Hon Ightm3Mnz/Ightm4.1Mnz B cells




Genotype
MGI:5484523
cx3
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Ightm4.1Mnz/Igh+
Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic
Background		 involves: 129 * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (55 available)
Ightm4.1Mnz mutation (0 available); any Igh mutation (43 available)
Trp53bp1tm1Jc mutation (1 available); any Trp53bp1 mutation (100 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immunoglobulin heavy chain V(D)J recombination ( J:194603 )
• following Rbbp8 depletion using short hairpin RNA, B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells
• treatment with a small molecular inhibitor of Mre11a or Wrn produces no effect on resection of microhomology at the junctions

hematopoietic system
abnormal immunoglobulin heavy chain V(D)J recombination ( J:194603 )
• following Rbbp8 depletion using short hairpin RNA, B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells
• treatment with a small molecular inhibitor of Mre11a or Wrn produces no effect on resection of microhomology at the junctions




Genotype
MGI:5484525
cx4
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Exo1tm1Wed/Exo1tm1Wed
Ightm4.1Mnz/Igh+
Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic
Background		 involves: 129 * C57BL/6 * CBA/JNCrlj * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (55 available)
Exo1tm1Wed mutation (0 available); any Exo1 mutation (45 available)
Ightm4.1Mnz mutation (0 available); any Igh mutation (43 available)
Trp53bp1tm1Jc mutation (1 available); any Trp53bp1 mutation (100 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immunoglobulin heavy chain V(D)J recombination ( J:194603 )
• B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells

hematopoietic system
abnormal immunoglobulin heavy chain V(D)J recombination ( J:194603 )
• B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells




Genotype
MGI:5484527
cx5
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Blmtm3Brd/Blmtm3Brd
Ightm4.1Mnz/Igh+
Trp53bp1tm1Jc/Trp53bp1tm1Jc
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (55 available)
Blmtm3Brd mutation (1 available); any Blm mutation (87 available)
Ightm4.1Mnz mutation (0 available); any Igh mutation (43 available)
Trp53bp1tm1Jc mutation (1 available); any Trp53bp1 mutation (100 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:194603 )
N
• B cells exhibit normal resection and junctional microhomology




Genotype
MGI:5484524
cx6
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Ightm4.1Mnz/Igh+
Genetic
Background		 involves: C57BL/6 * C57BL/6NCrlj * CBA/JNCrlj
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (55 available)
Ightm4.1Mnz mutation (0 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immunoglobulin heavy chain V(D)J recombination ( J:194603 )
• following Rbbp8 depletion using short hairpin RNA, B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells

hematopoietic system
abnormal immunoglobulin heavy chain V(D)J recombination ( J:194603 )
• following Rbbp8 depletion using short hairpin RNA, B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells




Genotype
MGI:5484526
cx7
Allelic
Composition		 Aicdatm1Hon/Aicdatm1Hon
Exo1tm1Wed/Exo1tm1Wed
Ightm4.1Mnz/Igh+
Genetic
Background		 involves: C57BL/6 * CBA/JNCrlj * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicdatm1Hon mutation (7 available); any Aicda mutation (55 available)
Exo1tm1Wed mutation (0 available); any Exo1 mutation (45 available)
Ightm4.1Mnz mutation (0 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal immunoglobulin heavy chain V(D)J recombination ( J:194603 )
• B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells

hematopoietic system
abnormal immunoglobulin heavy chain V(D)J recombination ( J:194603 )
• B cell exhibit reduced frequency of recombination joins displaying extensive resection and mean number of resected nucleotides created by I-SceI compared with wild-type cells




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory