All Phenotypes Mfn2<tm1.1Balo> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mfn2^tm1.1Balo
targeted mutation 1.1, Robert Balo
MGI:4442975

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mfn2^tm1.1Balo/Mfn2^tm1.1Balo	Not Specified	MGI:4442985

Allelic Composition	Mfn2^tm1.1Balo/Mfn2^tm1.1Balo
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mfn2^tm1.1Balo mutation (0 available); any Mfn2 mutation (27 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• mice die between E12.5 and birth

nervous system

abnormal axonal transport ( J:159219 )

• neurons exhibit abnormal mitochondria transport and delayed migration of mitochondria into the axons compared with wild-type cells

• however, transport of other organelles is normal

cellular

abnormal mitochondrial physiology ( J:159219 )

• neurons exhibit abnormal mitochondria transport and delayed migration of mitochondria into the axons compared with wild-type cells

• however, transport of other organelles is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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