All Phenotypes Tg(Gh1-cre)bKnmn MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lepr^tm1.1Chua/Lepr^tm1.1Chua Tg(Gh1-cre)bKnmn/0	involves: 129 * C57BL/6 * FVB	MGI:5014260
cn2	Lepr^tm1.1Chua/Lepr⁺ Tg(Gh1-cre)bKnmn/0	involves: 129 * C57BL/6 * FVB	MGI:5014261
cn3	Dlk1^tm1.1Jvs/Dlk1⁺ Tg(Gh1-cre)bKnmn/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5471937
cn4	Gt(ROSA)26Sor^{tm1(HBEGF)Awai}/Gt(ROSA)26Sor⁺ Tg(Gh1-cre)bKnmn/0	involves: C57BL/6 * FVB/N	MGI:4943177

Allelic Composition	Lepr^tm1.1Chua/Lepr^tm1.1Chua Tg(Gh1-cre)bKnmn/0
Genetic Background	involves: 129 * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^tm1.1Chua mutation (1 available); any Lepr mutation (121 available)
Tg(Gh1-cre)bKnmn mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality, incomplete penetrance ( J:173444 )

• litters from F3 generation mutant dams are smaller than those from cre-negative dams or mutants from the F1or F2 generations; litter size of female mutants of the F1 or F2 generations conform to the expected size

growth/size/body

increased lean body mass ( J:173444 )

• 10 month-old F3 females show a significant increase in lean body mass; 3.5 month-old males and females and 10 month-old males do not exhibit any increase

increased body weight ( J:173444 )

• growth rates are identical to controls up to 3 months of age but mean body weights for F3 generation males and females diverge from controls at 4 and 6.5 months, respectively

• at 9 months, F3 females are 46% heavier than controls but after 9 months, females lose weight with the average weight no longer being different from controls; males are significantly heavier than controls by 4 months of age with the difference continuing throughout life (at least 12-13 months)

obese ( J:173444 )

• F3 male mutants develop obesity with age

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:173444 )

N	• serum leptin and insulin levels are not different from controls in 3-4 month-old F3 males or females (all young adult groups even if group contained obese animals); no changes are observed in serum Igf1 levels

increased circulating leptin level ( J:173444 )

• leptin levels rise with obesity in older male and female mutants

decreased circulating growth hormone level ( J:173444 )

• levels are reduced by 72% in F3 generation adult males and by 50% in F3 female adults

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:173444 )

N	• despite reduction in GH-positive somatotroph numbers, there is no change in overall number of pituitary cells, or changes in pituitary size or morphology

decreased somatotroph cell number ( J:173444 )

• in F2 and F3 generation male and female mice, there is a significant decrease in growth hormone-positive cells

adipose tissue

increased total body fat amount ( J:173444 )

• some F3 generation animals were analyzed by DEXA (dual-energy x-ray absorptiometry) to look for changes in fat and lean mass

• 3.5 month-old F3 males show signficantl increases in grams of body fat; females show significant increases in fat mass at 3.5 and (in a small subset) at 10 months

nervous system

decreased somatotroph cell number ( J:173444 )

• in F2 and F3 generation male and female mice, there is a significant decrease in growth hormone-positive cells

reproductive system

reproductive system phenotype ( J:173444 )

N	• timing of puberty is normal in mutants

Allelic Composition	Lepr^tm1.1Chua/Lepr⁺ Tg(Gh1-cre)bKnmn/0
Genetic Background	involves: 129 * C57BL/6 * FVB

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lepr^tm1.1Chua mutation (1 available); any Lepr mutation (121 available)
Tg(Gh1-cre)bKnmn mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

decreased somatotroph cell number ( J:173444 )

• in F1 generation males, a significant decrease in growth hormone-positive somatrophs is observed

nervous system

decreased somatotroph cell number ( J:173444 )

• in F1 generation males, a significant decrease in growth hormone-positive somatrophs is observed

reproductive system

reproductive system phenotype ( J:173444 )

N	• mice are fertile

Allelic Composition	Dlk1^tm1.1Jvs/Dlk1⁺ Tg(Gh1-cre)bKnmn/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dlk1^tm1.1Jvs mutation (1 available); any Dlk1 mutation (34 available)
Tg(Gh1-cre)bKnmn mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:194130 )

N	• mice exhibit normal survival

growth/size/body

growth/size/body region phenotype ( J:194130 )

N	• mice exhibit normal growth

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

abnormal circulating hormone level ( J:169459 )

decreased circulating insulin level ( J:169459 )

• in diphtheria toxin-treated mice when a high-fat diet or a low-fat diet

decreased circulating insulin-like growth factor I level ( J:169459 )

• in diphtheria toxin-treated mice fed a high-fat or low-fat diet

increased circulating leptin level ( J:169459 )

• in diphtheria toxin-treated mice

decreased circulating growth hormone level ( J:169459 )

• in diphtheria toxin-treated mice fed a high-fat or low-fat diet

abnormal energy expenditure ( J:169459 )

decreased energy expenditure ( J:169459 )

• in diphtheria toxin-treated mice fed a low-fat during the nocturnal phase or when mice are fed a high-fat diet

abnormal gas homeostasis ( J:169459 )

decreased oxygen consumption ( J:169459 )

• in diphtheria toxin-treated mice fed a low-fat during the nocturnal phase

increased respiratory quotient ( J:169459 )

• in diphtheria toxin-treated mice fed a low-fat

abnormal glucose homeostasis ( J:169459 )

decreased circulating glucose level ( J:169459 )

• in diphtheria toxin-treated mice when fed standard chow

• in diphtheria toxin-treated mice when fed a high-fat diet or a low-fat diet during an insulin tolerance test

impaired glucose tolerance ( J:169459 )

• in diphtheria toxin-treated mice fed a high-fat

increased insulin sensitivity ( J:169459 )

• in diphtheria toxin-treated mice when fed standard chow, a high-fat diet, or a low-fat diet

decreased liver triglyceride level ( J:169459 )

• in diphtheria toxin-treated mice fed a high-fat

endocrine/exocrine glands

decreased somatotroph cell number ( J:169459 )

• in diphtheria toxin-treated mice

small adenohypophysis ( J:169459 )

• in diphtheria toxin-treated mice

adipose tissue

increased subcutaneous adipose tissue amount ( J:169459 )

• in diphtheria toxin-treated mice

increased total body fat amount ( J:169459 )

• in diphtheria toxin-treated mice fed standard chow or a high fat diet

increased retroperitoneal fat pad weight ( J:169459 )

• in diphtheria toxin-treated mice

growth/size/body

decreased lean body mass ( J:169459 )

• in diphtheria toxin-treated mice

decreased body weight ( J:169459 )

• in diphtheria toxin-treated mice fed a high fat diet

liver/biliary system

decreased liver triglyceride level ( J:169459 )

• in diphtheria toxin-treated mice fed a high-fat

decreased liver weight ( J:169459 )

• in diphtheria toxin-treated mice fed standard chow or a high fat diet

nervous system

decreased somatotroph cell number ( J:169459 )

• in diphtheria toxin-treated mice

small adenohypophysis ( J:169459 )

• in diphtheria toxin-treated mice

behavior/neurological

decreased fluid intake ( J:169459 )

• in diphtheria toxin-treated mice fed a low-fat

integument

increased subcutaneous adipose tissue amount ( J:169459 )

• in diphtheria toxin-treated mice

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
isolated growth hormone deficiency		DOID:0060870		J:169459

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