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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Podxltm1Parl
targeted mutation 1, Roberto Parrilla
MGI:4442892
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Podxltm1Parl/Podxltm1Parl
Podxl2tm1c(EUCOMM)Wtsi/Podxl2tm1c(EUCOMM)Wtsi
Tg(Pax3-cre)1Joe/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * SJL MGI:6711207
cn2
 		Podxltm1Parl/Podxl+
Tg(Mylpf-cre)3Kraj/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N MGI:4442893
cn3
 		Podxltm1Parl/Podxltm1Parl
Tg(Mylpf-cre)3Kraj/? 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N MGI:4442896
cn4
 		Podxltm1Parl/Podxltm1Parl
Podxl2tm1c(EUCOMM)Wtsi/Podxl2tm1c(EUCOMM)Wtsi
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:6711208


Genotype
MGI:6711207
cn1
Allelic
Composition		 Podxltm1Parl/Podxltm1Parl
Podxl2tm1c(EUCOMM)Wtsi/Podxl2tm1c(EUCOMM)Wtsi
Tg(Pax3-cre)1Joe/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * SJL
Cell Lines EPD0647_7_C06
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Podxl2tm1c(EUCOMM)Wtsi mutation (0 available); any Podxl2 mutation (26 available)
Podxltm1Parl mutation (0 available); any Podxl mutation (16 available)
Tg(Pax3-cre)1Joe mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:240523 )
N
• mice show no delay in timely lumen formation in developing epithelial tubules in the kidney at E14.5




Genotype
MGI:4442893
cn2
Allelic
Composition		 Podxltm1Parl/Podxl+
Tg(Mylpf-cre)3Kraj/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Podxltm1Parl mutation (0 available); any Podxl mutation (16 available)
Tg(Mylpf-cre)3Kraj mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype




Genotype
MGI:4442896
cn3
Allelic
Composition		 Podxltm1Parl/Podxltm1Parl
Tg(Mylpf-cre)3Kraj/?
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Podxltm1Parl mutation (0 available); any Podxl mutation (16 available)
Tg(Mylpf-cre)3Kraj mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
enlarged brain ventricles ( J:158322 )
• the ventricular spaces were enlarged

cardiovascular system
abnormal carotid artery morphology ( J:158322 )
• the carotid arteries are thicker than the wild type control
abnormal capillary morphology ( J:158322 )
• increased number of capillaries lining the intraventricular spaces




Genotype
MGI:6711208
cn4
Allelic
Composition		 Podxltm1Parl/Podxltm1Parl
Podxl2tm1c(EUCOMM)Wtsi/Podxl2tm1c(EUCOMM)Wtsi
Six2tm1(tTA,tetO-EGFP/cre)Amc/Six2+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Podxl2tm1c(EUCOMM)Wtsi mutation (0 available); any Podxl2 mutation (26 available)
Podxltm1Parl mutation (0 available); any Podxl mutation (16 available)
Six2tm1(tTA,tetO-EGFP/cre)Amc mutation (0 available); any Six2 mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:240523 )
• mice die in the neonatal period

renal/urinary system
renal/urinary system phenotype ( J:240523 )
N
• mice show no obvious defects in nephron lumen formation or luminal continuity indicating normal early stages of nephrogenesis




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory