All Phenotypes Podxl<tm1Parl> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Podxl^tm1Parl
targeted mutation 1, Roberto Parrilla
MGI:4442892

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Podxl^tm1Parl/Podxl^tm1Parl Podxl2^{tm1c(EUCOMM)Wtsi}/Podxl2^{tm1c(EUCOMM)Wtsi} Tg(Pax3-cre)1Joe/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * SJL	MGI:6711207
cn2	Podxl^tm1Parl/Podxl⁺ Tg(Mylpf-cre)3Kraj/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N	MGI:4442893
cn3	Podxl^tm1Parl/Podxl^tm1Parl Tg(Mylpf-cre)3Kraj/?	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N	MGI:4442896
cn4	Podxl^tm1Parl/Podxl^tm1Parl Podxl2^{tm1c(EUCOMM)Wtsi}/Podxl2^{tm1c(EUCOMM)Wtsi} Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL	MGI:6711208

Allelic Composition	Podxl^tm1Parl/Podxl^tm1Parl Podxl2^{tm1c(EUCOMM)Wtsi}/Podxl2^{tm1c(EUCOMM)Wtsi} Tg(Pax3-cre)1Joe/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * C57BL/6N * SJL
Cell Lines	EPD0647_7_C06

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Podxl2^{tm1c(EUCOMM)Wtsi} mutation (0 available); any Podxl2 mutation (25 available)
Podxl^tm1Parl mutation (0 available); any Podxl mutation (18 available)
Tg(Pax3-cre)1Joe mutation (0 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:240523 )

N	• mice show no delay in timely lumen formation in developing epithelial tubules in the kidney at E14.5

Allelic Composition	Podxl^tm1Parl/Podxl⁺ Tg(Mylpf-cre)3Kraj/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Podxl^tm1Parl mutation (0 available); any Podxl mutation (18 available)
Tg(Mylpf-cre)3Kraj mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:158322 )

Allelic Composition	Podxl^tm1Parl/Podxl^tm1Parl Tg(Mylpf-cre)3Kraj/?
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CD-1 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Podxl^tm1Parl mutation (0 available); any Podxl mutation (18 available)
Tg(Mylpf-cre)3Kraj mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

enlarged brain ventricles ( J:158322 )

• the ventricular spaces were enlarged

cardiovascular system

abnormal carotid artery morphology ( J:158322 )

• the carotid arteries are thicker than the wild type control

abnormal capillary morphology ( J:158322 )

• increased number of capillaries lining the intraventricular spaces

Allelic Composition	Podxl^tm1Parl/Podxl^tm1Parl Podxl2^{tm1c(EUCOMM)Wtsi}/Podxl2^{tm1c(EUCOMM)Wtsi} Six2^{tm1(tTA,tetO-EGFP/cre)Amc}/Six2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

neonatal lethality, complete penetrance ( J:240523 )

• mice die in the neonatal period

renal/urinary system

renal/urinary system phenotype ( J:240523 )

N	• mice show no obvious defects in nephron lumen formation or luminal continuity indicating normal early stages of nephrogenesis

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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