Analysis Tools|
Allele Symbol Allele Name Allele ID |
Il7rtm1.1(icre)Hrr targeted mutation 1.1, Hans-Reimer Rodewald MGI:4441349 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• after two consecutive intranasal doses of IL-25, mRNA expression of Rnase2a [ribonuclease, RNase A family, 2A (liver, eosinophil-derived neurotoxin), also known as Ear11] is nearly absent in sorted CD45+CD11c+SiglecF+F4/80+ alveolar macrophages, whereas Rnase2a/Ear11 expression is highly elevated in alveolar macrophages purified from IL-25-challenged Il7rtm1.1(icre)Hrr heterozygous controls
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• after two consecutive intranasal doses of IL-25, total lung neutrophil number and neutrophil infiltration in the bronchoalveolar lavage (BAL) is significantly lower than in IL-25-challenged Il7rtm1.1(icre)Hrr heterozygous controls
• complementation of IL-25 challenge with recombinant mouse (rm)Rnase2a fails to induce neutrophil recruitment in the lung
• however, unchallenged mice show a normal total lung neutrophil number/0.1g tissue relative to nave Il7rtm1.1(icre)Hrr heterozygous controls
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• after two consecutive intranasal doses of IL-25, mRNA expression of Rnase2a [ribonuclease, RNase A family, 2A (liver, eosinophil-derived neurotoxin), also known as Ear11] is nearly absent in sorted CD45+CD11c+SiglecF+F4/80+ alveolar macrophages, whereas Rnase2a/Ear11 expression is highly elevated in alveolar macrophages purified from IL-25-challenged Il7rtm1.1(icre)Hrr heterozygous controls
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• after two consecutive intranasal doses of IL-25, total lung neutrophil number and neutrophil infiltration in the bronchoalveolar lavage (BAL) is significantly lower than in IL-25-challenged Il7rtm1.1(icre)Hrr heterozygous controls
• complementation of IL-25 challenge with recombinant mouse (rm)Rnase2a fails to induce neutrophil recruitment in the lung
• however, unchallenged mice show a normal total lung neutrophil number/0.1g tissue relative to nave Il7rtm1.1(icre)Hrr heterozygous controls
|
|
• after two consecutive intranasal doses of IL-25, mRNA expression of Rnase2a [ribonuclease, RNase A family, 2A (liver, eosinophil-derived neurotoxin), also known as Ear11] is nearly absent in sorted CD45+CD11c+SiglecF+F4/80+ alveolar macrophages, whereas Rnase2a/Ear11 expression is highly elevated in alveolar macrophages purified from IL-25-challenged Il7rtm1.1(icre)Hrr heterozygous controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 07/22/2025 MGI 6.24 |
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