About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adam22tm1.1Mejr
targeted mutation 1.1, Dies Meijer
MGI:4441313
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Adam22tm1.1Mejr/Adam22tm1.1Mejr
H2az2Tg(Wnt1-cre)11Rth/H2az2+ 		involves: 129S4/SvJaeSor * C57BL/6J * CBA/J MGI:4441314
cn2
 		Adam22tm1.1Mejr/Adam22tm1.1Mejr
Tg(Dhh-cre)1Mejr/0 		involves: 129S4/SvJaeSor * FVB/N MGI:4441315


Genotype
MGI:4441314
cn1
Allelic
Composition		 Adam22tm1.1Mejr/Adam22tm1.1Mejr
H2az2Tg(Wnt1-cre)11Rth/H2az2+
Genetic
Background		 involves: 129S4/SvJaeSor * C57BL/6J * CBA/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam22tm1.1Mejr mutation (0 available); any Adam22 mutation (71 available)
H2az2Tg(Wnt1-cre)11Rth mutation (2 available); any H2az2 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal neuron morphology ( J:158973 )
• mice exhibit promyelin arrested fibers unlike wild-type mice
abnormal myelination ( J:158973 )
• mice exhibit promyelin arrested fibers unlike wild-type mice




Genotype
MGI:4441315
cn2
Allelic
Composition		 Adam22tm1.1Mejr/Adam22tm1.1Mejr
Tg(Dhh-cre)1Mejr/0
Genetic
Background		 involves: 129S4/SvJaeSor * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam22tm1.1Mejr mutation (0 available); any Adam22 mutation (71 available)
Tg(Dhh-cre)1Mejr mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:158973 )
N
• motor neuron myelination is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory