All Phenotypes Prox1<tm4.1Gco> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Prox1^tm4.1Gco
targeted mutation 4.1, Guillermo Oliver
MGI:4441290

Summary

2 genotypes

Allelic Composition	Prox1^tm4.1Gco/Prox1^tm4.1Gco
Genetic Background	involves: 129S1/Sv * C57BL/10 * CBA/Ca

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prox1^tm4.1Gco mutation (0 available); any Prox1 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

edema ( J:158959 )

• severe edema is observed at E13.5

immune system

• at level of jugular lymph sacs, reduction in number of lymphatic endothelial cells (LECs) is detected compared to heterozygous controls

• along anteroposterior axis of embryo, only a few Prox1+ve LECs that have abnormally aggregated around the jugular vein are detected

Allelic Composition	Prox1^tm4.1Gco/Prox1⁺
Genetic Background	involves: 129S1/Sv * C57BL/10 * CBA/Ca

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Prox1^tm4.1Gco mutation (0 available); any Prox1 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:158959 )

N	• embryos show no obvious edema at E15.5

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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