Phenotypes associated with this allele

• Allele Symbol: Tie1^tm1Scba
• Allele Name: targeted mutation 1, Scott Baldwin
• Allele ID: MGI:4441286
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tie1^tm1Scba/Tie1^tm1Scba	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:4441293

Genotype
MGI:4441293

hm1

• Allelic Composition: Tie1^tm1Scba/Tie1^tm1Scba
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:158668 )

• few mice survive to adulthood

prenatal lethality, incomplete penetrance ( J:158668 )

• rarely do mice die before E18.5

cardiovascular system

cardiovascular system phenotype ( J:158668 )

N • from E14.5 through E17.5, mice exhibit normal blood vessels

abnormal lymph circulation ( J:158668 )

• at E17.5, mice exhibit impaired lymphatic capillary network function compared with wild-type mice

hemorrhage ( J:158668 )

• after E16.5, 35% of mice exhibit hemorrhage at the tips of the tail and, occasionally, the tips of toes unlike wild-type mice

homeostasis/metabolism

edema ( J:158668 )

• before E16.5, most mice exhibit mild to severe edema unlike wild-type mice

• mice exhibit extensive interstitial edema unlike wild-type mice

immune system

abnormal lymph circulation ( J:158668 )

• at E17.5, mice exhibit impaired lymphatic capillary network function compared with wild-type mice

abnormal lymphatic vessel morphology ( J:158668 )

• at E13.5, lymphatic capillaries in the head dermis near the developing ear and in limb skin are dilated and disorganized unlike in wild-type mice

• at E13.5, lymphatic defects are less severe than in Tie1^tm1.1Scba mice

• at E14.5, lymphatic vessels are disorganized and mildly dilated compared to in wild-type mice

• at E15.5, lymphatic vessels are dilated and start to regress in some areas unlike in wild-type mice

• at E16.5, dermal lymphatic vessels are abnormal compared to in wild-type mice

• at E17.5, lymphatic vessels are dilated, disorganized, and irregular compared to in wild-type mice

• in the head skin, mice exhibit incomplete lymphatic vessel network patterning with increased number of blind beginnings compared with wild-type mice

• unlike in wild-type mice, the density of lymphatic vessels increases until E15.5 when regression is observed

• at E16.5, E17.5, and E18.5, lymphatic vessels in the heart and diaphragm are thin, dilated, and disorganized compared to in wild-type mice

abnormal lymphangiogenesis ( J:158668 )

• at E11.5 and E12.5, proliferation of lymphatic endothelial cells is increased compared to in wild-type mice

• at E13.5, apoptosis of lymphatic endothelial cells is greater than in wild-type mice

• at E15.5, and E17.5, apoptosis of lymphatic endothelial cells in the dermis is increased compared to in wild-type mice

• however, proliferation of lymphatic endothelial cells is normal by E13.5 and expression of marks is normal

lymphatic vessel hyperplasia ( J:158668 )

• at E13.5, jugular lymph sacs are larger than in wild-type mice