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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rev3ltm2.1Rwd
targeted mutation 2.1, Richard D Wood
MGI:4441207
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rev3ltm1Rwd/Rev3ltm2.1Rwd
Trp53tm1Brd/Trp53tm1Brd
Tg(MMTV-cre)1Mam/0 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:4441274
cn2
 		Rev3ltm1Rwd/Rev3ltm2.1Rwd
Trp53tm1Brd/Trp53+
Tg(MMTV-cre)1Mam/0 		involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N MGI:4441276
cn3
 		Rev3ltm1Rwd/Rev3ltm2.1Rwd
Tg(MMTV-cre)1Mam/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB MGI:4441273


Genotype
MGI:4441274
cn1
Allelic
Composition		 Rev3ltm1Rwd/Rev3ltm2.1Rwd
Trp53tm1Brd/Trp53tm1Brd
Tg(MMTV-cre)1Mam/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rev3ltm1Rwd mutation (0 available); any Rev3l mutation (118 available)
Rev3ltm2.1Rwd mutation (2 available); any Rev3l mutation (118 available)
Tg(MMTV-cre)1Mam mutation (1 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:158922 )
• mean survival is 91 days compared with 134 to 117 days for Trp53tm1Brd homozygous control mice

neoplasm
increased T cell derived lymphoma incidence ( J:158922 )
• in all mice develop thymic lymphomas compared with 70% to 77% of Trp53tm1Brd homozygous control mice
• tumors are frequently oligoclonal
• incidence of thymic lymphomas is increased while latency to development of tumors is decreased compared with Trp53tm1Brd homozygous control mice

endocrine/exocrine glands
increased T cell derived lymphoma incidence ( J:158922 )
• in all mice develop thymic lymphomas compared with 70% to 77% of Trp53tm1Brd homozygous control mice
• tumors are frequently oligoclonal
• incidence of thymic lymphomas is increased while latency to development of tumors is decreased compared with Trp53tm1Brd homozygous control mice




Genotype
MGI:4441276
cn2
Allelic
Composition		 Rev3ltm1Rwd/Rev3ltm2.1Rwd
Trp53tm1Brd/Trp53+
Tg(MMTV-cre)1Mam/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S7/SvEvBrd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rev3ltm1Rwd mutation (0 available); any Rev3l mutation (118 available)
Rev3ltm2.1Rwd mutation (2 available); any Rev3l mutation (118 available)
Tg(MMTV-cre)1Mam mutation (1 available)
Trp53tm1Brd mutation (5 available); any Trp53 mutation (232 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:158922 )
• 11 of 36 mice develop mammary tumors consisting of solid carcinoma, carcinosarcoma, adenosquamous carcinoma, and osteosarcoma
• incidence of mammary tumors is increased while latency to development of tumors is decreased compared with Trp53tm1Brd heterozygotes
increased carcinoma incidence ( J:158922 )
• in the mammary tissue of some mice
increased osteosarcoma incidence ( J:158922 )
• in the mammary tissue of one mouse

integument
increased mammary gland tumor incidence ( J:158922 )
• 11 of 36 mice develop mammary tumors consisting of solid carcinoma, carcinosarcoma, adenosquamous carcinoma, and osteosarcoma
• incidence of mammary tumors is increased while latency to development of tumors is decreased compared with Trp53tm1Brd heterozygotes

skeleton
increased osteosarcoma incidence ( J:158922 )
• in the mammary tissue of one mouse

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:158922 )
• 11 of 36 mice develop mammary tumors consisting of solid carcinoma, carcinosarcoma, adenosquamous carcinoma, and osteosarcoma
• incidence of mammary tumors is increased while latency to development of tumors is decreased compared with Trp53tm1Brd heterozygotes




Genotype
MGI:4441273
cn3
Allelic
Composition		 Rev3ltm1Rwd/Rev3ltm2.1Rwd
Tg(MMTV-cre)1Mam/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rev3ltm1Rwd mutation (0 available); any Rev3l mutation (118 available)
Rev3ltm2.1Rwd mutation (2 available); any Rev3l mutation (118 available)
Tg(MMTV-cre)1Mam mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased mammary gland tumor incidence ( J:158922 )
• 6 of 24 mice develop mammary tumors consisting of carcinosarcoma, solid carcinoma, and adenosquamous carcinoma
increased carcinoma incidence ( J:158922 )
• in the mammary tissue of some mice

integument
increased mammary gland tumor incidence ( J:158922 )
• 6 of 24 mice develop mammary tumors consisting of carcinosarcoma, solid carcinoma, and adenosquamous carcinoma

endocrine/exocrine glands
increased mammary gland tumor incidence ( J:158922 )
• 6 of 24 mice develop mammary tumors consisting of carcinosarcoma, solid carcinoma, and adenosquamous carcinoma




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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory