All Phenotypes Runx1<tm1.1Stkd> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Runx1^tm1.1Stkd
targeted mutation 1.1, Shu Takeda
MGI:4440931

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Runx1^tm1.1Stkd/Runx1^tm1.1Stkd Tg(Col2a1-cre)1Star/0	involves: C57BL/6	MGI:4440960
cn2	Runx1^tm1.1Stkd/Runx1^tm1.1Stkd Runx2^tm1Mjo/Runx2^tm1Mjo Tg(Col2a1-cre)1Star/0	involves: C57BL/6	MGI:4440962
cn3	Runx1^tm1.1Stkd/Runx1^tm1.1Stkd Tg(Prrx1-cre)1Cjt/0	involves: C57BL/6J * SJL/J	MGI:4440958
cn4	Runx1^tm1.1Stkd/Runx1^tm1.1Stkd Runx2^tm1Mjo/Runx2^tm1Mjo Tg(Prrx1-cre)1Cjt/0	involves: C57BL/6J * SJL/J	MGI:4440959

Allelic Composition	Runx1^tm1.1Stkd/Runx1^tm1.1Stkd Tg(Col2a1-cre)1Star/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1^tm1.1Stkd mutation (0 available); any Runx1 mutation (35 available)
Tg(Col2a1-cre)1Star mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

skeleton phenotype ( J:158761 )

N	• mice exhibit normal skeletal morphology

Allelic Composition	Runx1^tm1.1Stkd/Runx1^tm1.1Stkd Runx2^tm1Mjo/Runx2^tm1Mjo Tg(Col2a1-cre)1Star/0
Genetic Background	involves: C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1^tm1.1Stkd mutation (0 available); any Runx1 mutation (35 available)
Runx2^tm1Mjo mutation (0 available); any Runx2 mutation (42 available)
Tg(Col2a1-cre)1Star mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal skeleton morphology ( J:158761 )

• newborn mice are indistinguishable from Runx2^tm1Mjo homozygotes

Allelic Composition	Runx1^tm1.1Stkd/Runx1^tm1.1Stkd Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: C57BL/6J * SJL/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Runx1^tm1.1Stkd mutation (0 available); any Runx1 mutation (35 available)
Tg(Prrx1-cre)1Cjt mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

abnormal sternum morphology ( J:158761 )

• at 2 weeks of age, sternal development is delayed compared to in wild-type mice

• however, sternal development is normal by 3 weeks of age

abnormal xiphoid process morphology ( J:158761 )

• not mineralized in newborn mice

abnormal skeleton development ( J:158761 )

• at E14.5, sternal bar development is delayed compared to in wild-type mice

abnormal bone mineralization ( J:158761 )

• the xiphoid process is not mineralized in newborn mice unlike in wild-type mice

• however, by 3 weeks of age mice exhibit normal skeletal morphology

Allelic Composition	Runx1^tm1.1Stkd/Runx1^tm1.1Stkd Runx2^tm1Mjo/Runx2^tm1Mjo Tg(Prrx1-cre)1Cjt/0
Genetic Background	involves: C57BL/6J * SJL/J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:158761 )

• mice are non-viable

skeleton

absent sternum ( J:158761 )

• in newborn mice with no sign of sternal bar development

abnormal skeleton development ( J:158761 )

• sternal bar development is absent unlike in wild-type mice

abnormal chondrocyte differentiation ( J:158761 )

• at E13.5, reduced Alcian blue staining of cartilaginous matrices and marker expression compared to in wild-type mice indicate impaired chondrocyte differentiation

abnormal bone mineralization ( J:158761 )

• mice fail to exhibit mineralization of most skeletal elements, including the sternum, unlike in wild-type mice

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