Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac1tm1.1Pmt mutation
(0 available);
any
Hdac1 mutation
(36 available)
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cellular
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• MEFs with inducible Cre show a slow proliferation phenotype
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd79atm1(cre)Reth mutation
(3 available);
any
Cd79a mutation
(22 available)
Hdac1tm1.1Pmt mutation
(0 available);
any
Hdac1 mutation
(36 available)
Hdac2tm1.1Pmt mutation
(0 available);
any
Hdac2 mutation
(38 available)
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hematopoietic system
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• of pre BII cells and large pre BII cells
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• numbers of pre BI cells are reduced by 60%-80%
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• block in B cell differentiation as early as the pre BI cell stage
only 4.5% of pre B cells are in S phase compared to 80% for wild-type cells
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• only a very few B cells remain
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• spleen is virtually empty of circulating mature B cells
• in bone marrow, only a very few B cells remain
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• fewer than 1% of pre BII cell stage cells remain
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• virtually empty of circulating mature B cells
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immune system
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• of pre BII cells and large pre BII cells
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• numbers of pre BI cells are reduced by 60%-80%
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• block in B cell differentiation as early as the pre BI cell stage
only 4.5% of pre B cells are in S phase compared to 80% for wild-type cells
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• spleen is virtually empty of circulating mature B cells
• in bone marrow, only a very few B cells remain
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• fewer than 1% of pre BII cell stage cells remain
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• virtually empty of circulating mature B cells
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cellular
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• of pre BII cells and large pre BII cells
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac1tm1.1Pmt mutation
(0 available);
any
Hdac1 mutation
(36 available)
Hdac2tm1.1Pmt mutation
(0 available);
any
Hdac2 mutation
(38 available)
Tg(Fcer2a-cre)5Mbu mutation
(4 available)
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immune system
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• massive induction of apoptosis is detected when cells are cultured with LPS and IL4 or anti-IgM Fab
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• fail to proliferate in response to LPS and IL4 or anti-IgM Fab fragment stimulation
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hematopoietic system
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• massive induction of apoptosis is detected when cells are cultured with LPS and IL4 or anti-IgM Fab
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• fail to proliferate in response to LPS and IL4 or anti-IgM Fab fragment stimulation
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cellular
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• massive induction of apoptosis is detected when cells are cultured with LPS and IL4 or anti-IgM Fab
|
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• fail to proliferate in response to LPS and IL4 or anti-IgM Fab fragment stimulation
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac1tm1.1Pmt mutation
(0 available);
any
Hdac1 mutation
(36 available)
Hdac2tm1.1Pmt mutation
(0 available);
any
Hdac2 mutation
(38 available)
|
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cellular
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• Cre mediated recombination results in G1 arrest in MEFs
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• arrested Cre recombined MEFs die by apoptosis
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