Analysis Tools
nervous system
| N |
• normal morphology of sciatic nerves and spinal roots with no gross defects in axon sorting and myelination
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Allele Symbol Allele Name Allele ID |
Itga6tm2Egl targeted mutation 2, Elisabeth Georges-Labouesse MGI:4439081 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• normal morphology of sciatic nerves and spinal roots with no gross defects in axon sorting and myelination
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• injected cell derived tumors display increased blood vessel density
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• increase in tumor size 10 - 12 days after injection of Lewis lung carcinoma or murine melanoma cells compared to controls
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• injected cell derived tumors display increased blood vessel density
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• increase in vessel growth into implanted VEGF treated sponges and enhanced VEGF induced micro vessel sprouting in vitro compared to controls
• however, vessel density in untreated skin is not different from controls
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• delay in radial sorting of axons in the sciatic nerve at P5
• arrest in radial sorting, with axon bundles containing naked, mixed caliber axons
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• arrest in radial sorting, with axon bundles containing mixed caliber axons lacking ensheathing Schwann cells and having redundant and detached basal lamina
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• cells spread less when plated on laminin compared to wild-type cells
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• bundles of naked axons are seen at P15 and P28 in the sciatic nerve
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• viable
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• 5% of axons in the sciatic nerve have overly thin myelin for the caliber of the axon
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• 25% of axons in the sciatic nerve have overly thick myelin for the caliber of the axon
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• in the sciatic nerve, remak bundles contain axons that are greater than 1 um in diameter suggesting a defect in recognition or sorting of axons
• other large caliber axons in the sciatic nerve are sorted properly but not myelinated suggesting a delay in myelination
• some small caliber axons (less than 1 um in diameter) in the sciatic nerve are abnormally myelinated
• 5% of axons in the sciatic nerve have overly thin myelin for the caliber of the axon
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• occasional
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• cells spread less when plated on laminin compared to wild-type cells
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• in the sciatic nerve, remak bundles contain axons that are greater than 1 um in diameter suggesting a defect in recognition or sorting of axons
• other large caliber axons in the sciatic nerve are sorted properly but not myelinated suggesting a delay in myelination
• some small caliber axons (less than 1 um in diameter) in the sciatic nerve are abnormally myelinated
• 5% of axons in the sciatic nerve have overly thin myelin for the caliber of the axon
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• 25% of axons in the sciatic nerve have overly thick myelin for the caliber of the axon
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/30/2024 MGI 6.23 |
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