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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fbn2mz
mariusz
MGI:4438056
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fbn2mz/Fbn2mz involves: BALB/cAnNCrl * C3H/HeH MGI:4438065
ht2
 		Fbn2fp/Fbn2mz involves: BALB/cAnNCrl * C3H/HeH * C3HeB/FeHu * C57BL/6J MGI:4438066


Genotype
MGI:4438065
hm1
Allelic
Composition		 Fbn2mz/Fbn2mz
Genetic
Background		 involves: BALB/cAnNCrl * C3H/HeH
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn2mz mutation (0 available); any Fbn2 mutation (142 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Muscle weakness in Fbn2mz/Fbn2mz mice

muscle
increased skeletal muscle mass ( J:157998 )
• in the soleus muscle
abnormal muscle electrophysiology ( J:157998 )
• at 4 months, peak isometric tetanic force is higher than in wild-type muscle cells
• however, peak isometric stress is normal
muscle weakness ( J:157998 )
• generalized

behavior/neurological
abnormal motor capabilities/coordination/movement ( J:157998 )
• mice exhibit poor performance in the MoRAG test for measuring grasping and retrieval of food pellets compared with wild-type mice
decreased grip strength ( J:157998 )
• in the grip strength and wire maneuver tests

limbs/digits/tail
syndactyly ( J:157998 )
• with two or more adjacent toes on the hind limb paw

growth/size/body
decreased body size ( J:157998 )
postnatal growth retardation ( J:157998 )

skeleton

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
distal arthrogryposis DOID:0050646 OMIM:PS108120
 J:157998




Genotype
MGI:4438066
ht2
Allelic
Composition		 Fbn2fp/Fbn2mz
Genetic
Background		 involves: BALB/cAnNCrl * C3H/HeH * C3HeB/FeHu * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fbn2fp mutation (1 available); any Fbn2 mutation (142 available)
Fbn2mz mutation (0 available); any Fbn2 mutation (142 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Limb clasping, reduced grip strength, and syndactyly in Fbn2mz/Fbn2mz, Fbn2fp/Fbn2fp and Fbn2mz/Fbn2fp mice

behavior/neurological

muscle




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/03/2024
MGI 6.24 		The Jackson Laboratory