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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ahi1tm2.1Jgg
targeted mutation 2.1, Joseph G Gleeson
MGI:4437788
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ahi1tm1Jgg/Ahi1tm2.1Jgg
Tg(Pax6-cre,GFP)2Pgr/0 		involves: 129 * C57BL/6 * FVB/N MGI:4437797
cn2
 		Ahi1tm1Jgg/Ahi1tm2.1Jgg
Nphp1tm1Jgg/Nphp1+
Tg(Pax6-cre,GFP)2Pgr/0 		involves: 129 * C57BL/6 * FVB/N * NMRI MGI:4437798
cn3
 		Ahi1tm1Jgg/Ahi1tm2.1Jgg
Tg(Nes-cre)1Kln/0 		involves: 129 * C57BL/6 * FVB/N * SJL MGI:4437796


Genotype
MGI:4437797
cn1
Allelic
Composition		 Ahi1tm1Jgg/Ahi1tm2.1Jgg
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahi1tm1Jgg mutation (1 available); any Ahi1 mutation (80 available)
Ahi1tm2.1Jgg mutation (1 available); any Ahi1 mutation (80 available)
Tg(Pax6-cre,GFP)2Pgr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye




Genotype
MGI:4437798
cn2
Allelic
Composition		 Ahi1tm1Jgg/Ahi1tm2.1Jgg
Nphp1tm1Jgg/Nphp1+
Tg(Pax6-cre,GFP)2Pgr/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahi1tm1Jgg mutation (1 available); any Ahi1 mutation (80 available)
Ahi1tm2.1Jgg mutation (1 available); any Ahi1 mutation (80 available)
Nphp1tm1Jgg mutation (1 available); any Nphp1 mutation (26 available)
Tg(Pax6-cre,GFP)2Pgr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye




Genotype
MGI:4437796
cn3
Allelic
Composition		 Ahi1tm1Jgg/Ahi1tm2.1Jgg
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129 * C57BL/6 * FVB/N * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ahi1tm1Jgg mutation (1 available); any Ahi1 mutation (80 available)
Ahi1tm2.1Jgg mutation (1 available); any Ahi1 mutation (80 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:158019 )
N
• mice exhibit normal mortality through weaning

vision/eye
abnormal rod electrophysiology ( J:158019 )
• at P19, dark-adapted electrical activity is absent unlike in wild-type mice

nervous system
nervous system phenotype ( J:158019 )
N
• brain morphology is normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory