All Phenotypes Is(14)1Rdf MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Is(14)1Rdf
insertion, Chr 14, Riccardo Dalla-Favera 1
MGI:4437012

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Is(14)1Rdf Is(14)2Rdf/Del(14Trim13-Dleu2)4Rdf Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6	MGI:4437062
cn2	Is(14)1Rdf Is(14)5Rdf/Del(14Trim13-Rnaseh2b)6Rdf Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6	MGI:5305095
cn3	Is(14)1Rdf/Is(14)1Rdf Is(14)5Rdf/Is(14)5Rdf Cd19^tm1(cre)Cgn/Cd19⁺	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6	MGI:5305097

Allelic Composition	Is(14)1Rdf Is(14)2Rdf/Del(14Trim13-Dleu2)4Rdf Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Del(14Trim13-Dleu2)4Rdf mutation (0 available); any Del(14Trim13-Dleu2)4Rdf mutation (0 available)
Is(14)1Rdf mutation (0 available); any Is(14)1Rdf mutation (0 available)
Is(14)2Rdf mutation (3 available); any Is(14)2Rdf mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

increased B cell number ( J:156946 )

• monoclonal B cell lymphocytosis in some mice at 15 - 18 months of age

increased B-1a cell number ( J:156946 )

• at 15-18 months increased clonal population in the peripheral blood

increased spleen white pulp amount ( J:156946 )

• expansion or accumulation of small lymphocytes, with a pattern similar small cell lymphocytic leukemia (SLL) or B cell chronic lymphocytic leukemia (CLL) and with characteristic 'smudge' cells in some mice

immune system

increased B cell number ( J:156946 )

• monoclonal B cell lymphocytosis in some mice at 15 - 18 months of age

increased B-1a cell number ( J:156946 )

• at 15-18 months increased clonal population in the peripheral blood

increased spleen white pulp amount ( J:156946 )

neoplasm

increased leukemia incidence ( J:156946 )

• a fraction of mice have histological features of small cell lymphocytic leukemia (SLL) or B cell chronic lymphocytic leukemia (CLL)

increased B cell derived lymphoma incidence ( J:156946 )

• some of the CD5 negative tumors showed a mature B cell phenotype histologically reminiscent of human diffuse large B cell lymphoma, non-Hodgkin lymphoma

• a minority of CD5 negative tumors showed plasmacytic features similar to lymphoplasmacytic lymphoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:156946

Allelic Composition	Is(14)1Rdf Is(14)5Rdf/Del(14Trim13-Rnaseh2b)6Rdf Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Del(14Trim13-Rnaseh2b)6Rdf mutation (0 available); any Del(14Trim13-Rnaseh2b)6Rdf mutation (0 available)
Is(14)1Rdf mutation (0 available); any Is(14)1Rdf mutation (0 available)
Is(14)5Rdf mutation (1 available); any Is(14)5Rdf mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:179879 )

neoplasm

increased chronic lymphocytic leukemia incidence ( J:179879 )

increased lymphoma incidence ( J:179879 )

• mice develop B cell clonal lymphoproliferations, chronic lymphocytic leukemia , small cell lymphomas, and CD5- non-Hodgkin lymphomas

increased small lymphocytic lymphoma incidence ( J:179879 )

immune system

abnormal lymphopoiesis ( J:179879 )

• mice exhibit lymphoproliferation in the peripheral blood (IgM+CD5+B220^lo) with characteristics of chronic lymphocytic leukemia

• 42% of mice develop clonal lymphoproliferations

increased B cell number ( J:179879 )

• IgM+CD5+B220^lo

hematopoietic system

abnormal lymphopoiesis ( J:179879 )

• mice exhibit lymphoproliferation in the peripheral blood (IgM+CD5+B220^lo) with characteristics of chronic lymphocytic leukemia

• 42% of mice develop clonal lymphoproliferations

increased B cell number ( J:179879 )

• IgM+CD5+B220^lo

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:179879

Allelic Composition	Is(14)1Rdf/Is(14)1Rdf Is(14)5Rdf/Is(14)5Rdf Cd19^tm1(cre)Cgn/Cd19⁺
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd19^tm1(cre)Cgn mutation (11 available); any Cd19 mutation (56 available)
Is(14)1Rdf mutation (0 available); any Is(14)1Rdf mutation (0 available)
Is(14)5Rdf mutation (1 available); any Is(14)5Rdf mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:179879 )

neoplasm

increased chronic lymphocytic leukemia incidence ( J:179879 )

increased lymphoma incidence ( J:179879 )

• mice develop B cell clonal lymphoproliferations, chronic lymphocytic leukemia , small cell lymphomas, and CD5- non-Hodgkin lymphomas

increased small lymphocytic lymphoma incidence ( J:179879 )

immune system

abnormal lymphopoiesis ( J:179879 )

• mice exhibit lymphoproliferation in the peripheral blood (IgM+CD5+B220^lo) with characteristics of chronic lymphocytic leukemia

• 67% of mice develop clonal lymphoproliferations

increased B cell number ( J:179879 )

• IgM+CD5+B220^lo

hematopoietic system

abnormal lymphopoiesis ( J:179879 )

• mice exhibit lymphoproliferation in the peripheral blood (IgM+CD5+B220^lo) with characteristics of chronic lymphocytic leukemia

• 67% of mice develop clonal lymphoproliferations

increased B cell number ( J:179879 )

• IgM+CD5+B220^lo

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
chronic lymphocytic leukemia		DOID:1040	OMIM:109543 OMIM:151400 OMIM:609630 OMIM:612557 OMIM:612558 OMIM:612559	J:179879

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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