Phenotypes associated with this allele

• Allele Symbol: Smug1^{tm1a(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:4435952
• Summary: 6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Smug1^tm1a(EUCOMM)Hmgu/Smug1^tm1a(EUCOMM)Hmgu	involves: C57BL/6 * C57BL/6N	MGI:5505260
hm2	Smug1^tm1a(EUCOMM)Hmgu/Smug1^tm1a(EUCOMM)Hmgu	involves: C57BL/6 * C57BL/6N	MGI:5507884
cx3	Smug1^tm1a(EUCOMM)Hmgu/Smug1^tm1a(EUCOMM)Hmgu Ung^tm1Tld/Ung^tm1Tld	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N	MGI:5505261
cx4	Msh2^tm1Htr/Msh2^tm1Htr Smug1^tm1a(EUCOMM)Hmgu/Smug1^tm1a(EUCOMM)Hmgu Ung^tm1Tld/Ung^tm1Tld	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N	MGI:5505262
cx5	Smug1^tm1a(EUCOMM)Hmgu/Smug1^tm1a(EUCOMM)Hmgu Ung^tm1Tld/Ung^tm1Tld	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N	MGI:5507885
cx6	Msh2^tm1Htr/Msh2^tm1Htr Smug1^tm1a(EUCOMM)Hmgu/Smug1^tm1a(EUCOMM)Hmgu Ung^tm1Tld/Ung^tm1Tld	involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N	MGI:5507886

Genotype
MGI:5505260

hm1

• Allelic Composition: Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: HEPD0529_1_C05

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:197809 )

N • mice exhibit normal life expectancy

cellular

decreased sensitivity to induced cell death ( J:197809 )

• mouse embryonic fibroblasts are resistant to 5-hydroxymethyluridine toxicity compared with wild-type cells

impaired base-excision repair ( J:197809 )

• mice lack 5-hydroxymethyluracil excision activity compared with wild-type mice

• liver cells exhibit reduced 5-fluorouracil excision activity compared with wild-type cells

homeostasis/metabolism

impaired base-excision repair ( J:197809 )

• mice lack 5-hydroxymethyluracil excision activity compared with wild-type mice

• liver cells exhibit reduced 5-fluorouracil excision activity compared with wild-type cells

Genotype
MGI:5507884

hm2

• Allelic Composition: Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu}
• Genetic Background: involves: C57BL/6 * C57BL/6N
• Cell Lines: HEPD0529_1_B07

mortality/aging

mortality/aging ( J:197809 )

N • mice exhibit normal life expectancy

cellular

decreased sensitivity to induced cell death ( J:197809 )

• mouse embryonic fibroblasts are resistant to 5-hydroxymethyluridine toxicity compared with wild-type cells

impaired base-excision repair ( J:197809 )

• mice lack 5-hydroxymethyluracil excision activity compared with wild-type mice

• liver cells exhibit reduced 5-fluorouracil excision activity compared with wild-type cells

homeostasis/metabolism

impaired base-excision repair ( J:197809 )

• mice lack 5-hydroxymethyluracil excision activity compared with wild-type mice

• liver cells exhibit reduced 5-fluorouracil excision activity compared with wild-type cells

Genotype
MGI:5505261

cx3

• Allelic Composition: Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu}; Ung^tm1Tld/Ung^tm1Tld
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
• Cell Lines: HEPD0529_1_C05

mortality/aging

mortality/aging ( J:197809 )

N • mice exhibit normal life expectancy

cellular

impaired base-excision repair ( J:197809 )

• liver cells exhibit non-additive reduced 5-fluorouracil excision activity compared with wild-type cells

impaired mismatch repair ( J:197809 )

• mice lack uracil excision activity from a double-stranded oligodeoxyribonucleotide substrate containing a U:G mismatch

homeostasis/metabolism

impaired base-excision repair ( J:197809 )

• liver cells exhibit non-additive reduced 5-fluorouracil excision activity compared with wild-type cells

impaired mismatch repair ( J:197809 )

• mice lack uracil excision activity from a double-stranded oligodeoxyribonucleotide substrate containing a U:G mismatch

Genotype
MGI:5505262

cx4

• Allelic Composition: Msh2^tm1Htr/Msh2^tm1Htr; Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu}; Ung^tm1Tld/Ung^tm1Tld
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
• Cell Lines: HEPD0529_1_C05

mortality/aging

premature death ( J:197809 )

• mean life expectancy is 107 days compared with 223 days for Msh2^tm1Htr homozygotes

preweaning lethality, incomplete penetrance ( J:197809 )

• fewer than expected mice are identified at weaning

neoplasm

increased tumor incidence ( J:197809 )

• in all mice that die

increased lymphoma incidence ( J:197809 )

• in 4 of 5 mice with tumors

Genotype
MGI:5507885

cx5

• Allelic Composition: Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu}; Ung^tm1Tld/Ung^tm1Tld
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
• Cell Lines: HEPD0529_1_B07

mortality/aging

mortality/aging ( J:197809 )

N • mice exhibit normal life expectancy

cellular

impaired base-excision repair ( J:197809 )

• liver cells exhibit non-additive reduced 5-fluorouracil excision activity compared with wild-type cells

impaired mismatch repair ( J:197809 )

• mice lack uracil excision activity from a double-stranded oligodeoxyribonucleotide substrate containing a U:G mismatch

homeostasis/metabolism

impaired base-excision repair ( J:197809 )

• liver cells exhibit non-additive reduced 5-fluorouracil excision activity compared with wild-type cells

impaired mismatch repair ( J:197809 )

• mice lack uracil excision activity from a double-stranded oligodeoxyribonucleotide substrate containing a U:G mismatch

Genotype
MGI:5507886

cx6

• Allelic Composition: Msh2^tm1Htr/Msh2^tm1Htr; Smug1^{tm1a(EUCOMM)Hmgu}/Smug1^{tm1a(EUCOMM)Hmgu}; Ung^tm1Tld/Ung^tm1Tld
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * C57BL/6N
• Cell Lines: HEPD0529_1_B07

mortality/aging

premature death ( J:197809 )

• mean life expectancy is 107 days compared with 223 days for Msh2^tm1Htr homozygotes

preweaning lethality, incomplete penetrance ( J:197809 )

• fewer than expected mice are identified at weaning

neoplasm

increased tumor incidence ( J:197809 )

• in all mice that die

increased lymphoma incidence ( J:197809 )

• in 4 of 5 mice with tumors