Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gatad2btm1a(EUCOMM)Hmgu mutation
(1 available);
any
Gatad2b mutation
(24 available)
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mortality/aging
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• only 11 out of 169 pups born from heterozygous matings are homozygotes; these mice die soon after birth with no apparent morphological defects
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nervous system
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• at E16.5, the proportion of radial glial cells is significantly increased in the developing cortex
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• at E16.5, proportions of interneurons are consistently reduced in the developing cortex
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• at P0, most callosal axons fail to reach the contralateral hemisphere
• reduced midline crossing of commissural axons is associated with an abnormal arrangement of GFAP+ guidepost glia cells and a widening of the interhemispheric fissure
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• at E18.5, the proportion of cells expressing Tbr1 in layer V (co-expressing Ctip2) is significantly higher than in wild-type controls
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• embryonic brains exhibit reduced cortical thickness
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• at E18, brains show a virtually complete absence of GFAP expressing glia
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• at E16.5, the proportion of progenitor-like cells in the subventricular zone is significantly increased in the developing cortex whereas the proportion of ganglionic eminence cells is reduced
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cellular
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• at E16.5, the proportion of radial glial cells is significantly increased in the developing cortex
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gatad2btm1a(EUCOMM)Hmgu mutation
(1 available);
any
Gatad2b mutation
(24 available)
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mortality/aging
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N |
• mice survive to adulthood
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craniofacial
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• 85% of mice exhibit increased curvature of the nasion vs 14% of wild-type controls
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• mice exhibit a significantly broader snout than wild-type controls, as measured by the distance between the most lateral 3rd row of vibrissae
• however, no significant difference is observed in head width
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behavior/neurological
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N |
• mice do NOT exhibit spontaneous seizures at any age and show normal behavior in the grip strength test and the hanging test at 1 month of age
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• in a contextual fear conditioning task, mice exhibit significantly less freezing than wild-type controls in contextual testing 24 h after conditioning
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• mice exhibit significantly less freezing in cued conditioning during pre-tone and tone
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• mice exhibit novel environment-induced hyperactivity (total distance traveled) in the open field test
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• in the Barnes maze task, 12-wk-old mice perform worse than wild-type controls at finding the target hole across the acquisition phase
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• in the open field test, mice spend significantly more time exploring the periphery while avoiding the anxiety-provoking center
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• dams are not good mothers; litters derived from wild-type males bred with heterozygous females are nursed by wild-type foster females
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nervous system
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• at E16.5, the proportion of radial glial cells is significantly increased in the developing cortex
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• at E16.5, proportions of interneurons are consistently reduced in the developing cortex
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• at P0, significantly less callosal axons cross the midline and the number of midline astroglia cells is decreased
• decreased midline crossing of commissural axons is associated with an abnormal arrangement of GFAP+ guidepost glia cells and a widening of the interhemispheric fissure
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• embryonic brains exhibit abnormal density of layer-specific neurons in the cortex
• at E16.5, the frequency of cells co-expressing Satb2 and Ctip2 is significantly higher than in wild-type controls
• at E18.5, the proportion of cells expressing Tbr1 in layer V (co-expressing Ctip2) is significantly higher than in wild-type controls
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• embryonic brains exhibit reduced cortical thickness
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• at E18, all GFAP+ glia, including the glial wedge (GW), indusium griseum glia (IGG) and midline zipper glia (MZG) subtypes, are generally reduced
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• at E16.5, the proportion of progenitor-like cells in the subventricular zone is significantly increased in the developing cortex whereas the proportion of ganglionic eminence cells is reduced
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growth/size/body
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• 85% of mice exhibit increased curvature of the nasion vs 14% of wild-type controls
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• mice exhibit a significantly broader snout than wild-type controls, as measured by the distance between the most lateral 3rd row of vibrissae
• however, no significant difference is observed in head width
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cellular
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• at E16.5, the proportion of radial glial cells is significantly increased in the developing cortex
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• abnormal epigenetic transcriptional regulation of corticogenesis
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