Phenotypes associated with this allele

• Allele Symbol: Arhgef1^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4434048
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Arhgef1^tm1a(EUCOMM)Wtsi/Arhgef1^tm1a(EUCOMM)Wtsi	C57BL/6N-Arhgef1^tm1a(EUCOMM)Wtsi/Wtsi	MGI:5767567

Genotype
MGI:5767567

hm1

• Allelic Composition: Arhgef1^{tm1a(EUCOMM)Wtsi}/Arhgef1^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Arhgef1^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0177_5_G11

Data Sources

IMPC Data for Arhgef1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased erythrocyte cell number ( J:211773 )

IMPC - WTSI

increased hematocrit ( J:211773 )

♂

IMPC - WTSI

increased hemoglobin content ( J:211773 )

♀

IMPC - WTSI

increased plasmacytoid dendritic cell number ( J:211773 )

IMPC - WTSI

decreased dendritic cell number ( J:211773 )

IMPC - WTSI

decreased marginal zone B cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive NK cell number ( J:211773 )

IMPC - WTSI

decreased immature NK cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C-positive immature NK cell number ( J:211773 )

IMPC - WTSI

increased mature NK cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta memory T cell number ( J:211773 )

IMPC - WTSI

increased CD8-positive, alpha-beta memory T cell number ( J:211773 )

♂

IMPC - WTSI

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

increased Ly6C-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased monocyte cell number ( J:211773 )

IMPC - WTSI

increased Ly6C low monocyte number ( J:211773 )

IMPC - WTSI

immune system

increased plasmacytoid dendritic cell number ( J:211773 )

IMPC - WTSI

decreased dendritic cell number ( J:211773 )

IMPC - WTSI

decreased marginal zone B cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive NK cell number ( J:211773 )

IMPC - WTSI

decreased immature NK cell number ( J:211773 )

IMPC - WTSI

decreased Ly6C-positive immature NK cell number ( J:211773 )

IMPC - WTSI

increased mature NK cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

increased KLRG1-positive CD4-positive, CD25-positive, alpha-beta regulatory T cell number ( J:211773 )

IMPC - WTSI

increased CD4-positive, alpha-beta memory T cell number ( J:211773 )

IMPC - WTSI

increased CD8-positive, alpha-beta memory T cell number ( J:211773 )

♂

IMPC - WTSI

increased effector memory CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased CD8-positive, alpha-beta T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker CD4-positive NK T cell number ( J:211773 )

IMPC - WTSI

increased Ly6C-positive NK T cell number ( J:211773 )

IMPC - WTSI

decreased memory-marker gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased gamma-delta T cell number ( J:211773 )

IMPC - WTSI

increased monocyte cell number ( J:211773 )

IMPC - WTSI

increased Ly6C low monocyte number ( J:211773 )

IMPC - WTSI

mortality/aging

preweaning lethality, incomplete penetrance ( J:211773 )

IMPC - WTSI