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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Nfkbidtm1a(EUCOMM)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4432464
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Nfkbidtm1a(EUCOMM)Wtsi/Nfkbidtm1a(EUCOMM)Wtsi involves: C57BL/6N MGI:5429175
ht2
 		Nfkbidtm1a(EUCOMM)Wtsi/Nfkbid+ C57BL/6N-Nfkbidtm1a(EUCOMM)Wtsi/Cnrm MGI:5782144


Genotype
MGI:5429175
hm1
Allelic
Composition		 Nfkbidtm1a(EUCOMM)Wtsi/Nfkbidtm1a(EUCOMM)Wtsi
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbidtm1a(EUCOMM)Wtsi mutation (1 available); any Nfkbid mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
abnormal class switch recombination ( J:185495 )
• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice
decreased IgG level ( J:185495 )
• response in response to recombinant Semliki Forest virus (SFV) encoded antigen
decreased IgM level ( J:185495 )
• following NP-Ficoll immunization

hematopoietic system
abnormal class switch recombination ( J:185495 )
• mice exhibit reduced class-switch antibody response in response to recombinant Semliki Forest virus (SFV) encoded antigen compared with control mice
decreased IgG level ( J:185495 )
• response in response to recombinant Semliki Forest virus (SFV) encoded antigen
decreased IgM level ( J:185495 )
• following NP-Ficoll immunization




Genotype
MGI:5782144
ht2
Allelic
Composition		 Nfkbidtm1a(EUCOMM)Wtsi/Nfkbid+
Genetic
Background		 C57BL/6N-Nfkbidtm1a(EUCOMM)Wtsi/Cnrm
Cell Lines EPD0100_4_A03
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfkbidtm1a(EUCOMM)Wtsi mutation (1 available); any Nfkbid mutation (22 available)
Data Sources
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal behavior ( J:165965 )
IMPC - HMGU

hematopoietic system

homeostasis/metabolism

immune system




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/21/2024
MGI 6.23 		The Jackson Laboratory