Phenotypes associated with this allele

• Allele Symbol: Cep250^{tm1a(EUCOMM)Wtsi}
• Allele Name: targeted mutation 1a, Wellcome Trust Sanger Institute
• Allele ID: MGI:4431949
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cep250^tm1a(EUCOMM)Wtsi/Cep250^tm1a(EUCOMM)Wtsi	C57BL/6N-Cep250^tm1a(EUCOMM)Wtsi/Wtsi	MGI:6262108
cn2	Cep250^tm1a(EUCOMM)Wtsi/Cep250^tm1a(EUCOMM)Wtsi Tg(Stra8-icre)1Reb/0	involves: C57BL/6N	MGI:7444373

Genotype
MGI:6262108

hm1

• Allelic Composition: Cep250^{tm1a(EUCOMM)Wtsi}/Cep250^{tm1a(EUCOMM)Wtsi}
• Genetic Background: C57BL/6N-Cep250^{tm1a(EUCOMM)Wtsi}/Wtsi
• Cell Lines: EPD0430_3_A05

Data Sources

IMPC Data for Cep250

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

adipose tissue

increased total body fat amount ( J:211773 )

♀

IMPC - WTSI

behavior/neurological

absent pinna reflex ( J:211773 )

♂

IMPC - WTSI

hearing/vestibular/ear

abnormal auditory brainstem response ( J:211773 )

IMPC - WTSI

reproductive system

male infertility ( J:211773 )

♂

IMPC - WTSI

Genotype
MGI:7444373

cn2

• Allelic Composition: Cep250^{tm1a(EUCOMM)Wtsi}/Cep250^{tm1a(EUCOMM)Wtsi}; Tg(Stra8-icre)1Reb/0
• Genetic Background: involves: C57BL/6N

cellular

decreased male germ cell number ( J:326549 )

♂ • reduction of germ cells was observed in mutant testes at 8 weeks

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:326549 )

♂ • fewer seminiferous tubules are present

small seminiferous tubules ( J:326549 )

♂

small testis ( J:326549 )

♂ • at 8 and 15 weeks of age

reproductive system

decreased male germ cell number ( J:326549 )

♂ • reduction of germ cells was observed in mutant testes at 8 weeks

abnormal seminiferous tubule morphology ( J:326549 )

♂ • fewer seminiferous tubules are present

small seminiferous tubules ( J:326549 )

♂

small testis ( J:326549 )

♂ • at 8 and 15 weeks of age