All Phenotypes Ephb2<tm3.1Jf> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ephb2^tm3.1Jf
targeted mutation 3.1, Jonas Frisen
MGI:4431255

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ephb2^tm3.1Jf/Ephb2^tm3.1Jf	involves: 129S1/Sv * 129X1/SvJ	MGI:5306597
ht2	Ephb2^tm3.1Jf/Ephb2⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5306596
cx3	Ephb2^tm3.1Jf/Ephb2^tm3.1Jf Ephb3^tm1Kln/Ephb3^tm1Kln	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * CD-1	MGI:4431258

Allelic Composition	Ephb2^tm3.1Jf/Ephb2^tm3.1Jf
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb2^tm3.1Jf mutation (0 available); any Ephb2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:176056 )

• most mice exhibit ventral-temporal (VT) retinal ganglion cell axon mapping defects compared with control mice

Allelic Composition	Ephb2^tm3.1Jf/Ephb2⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb2^tm3.1Jf mutation (0 available); any Ephb2 mutation (66 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal axon morphology ( J:176056 )

• some mice exhibit ventral-temporal (VT) retinal ganglion cell axon mapping defects compared with control mice

Allelic Composition	Ephb2^tm3.1Jf/Ephb2^tm3.1Jf Ephb3^tm1Kln/Ephb3^tm1Kln
Genetic Background	involves: 129S1/Sv * 129S2/SvPas * 129X1/SvJ * CD-1

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ephb2^tm3.1Jf mutation (0 available); any Ephb2 mutation (66 available)
Ephb3^tm1Kln mutation (1 available); any Ephb3 mutation (52 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:157019 )

N	• unlike in Ephb2^tm2Paw Ephb3^tm1Kln double mutants, Paneth cell positioning is normal

abnormal small intestinal crypt cell proliferation ( J:157019 )

• the number of mitotic cells in intestinal crypts was reduced to a similar extent as in Ephb2^tm2Paw Ephb3^tm1Kln double mutants

cellular

abnormal small intestinal crypt cell proliferation ( J:157019 )

• the number of mitotic cells in intestinal crypts was reduced to a similar extent as in Ephb2^tm2Paw Ephb3^tm1Kln double mutants

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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