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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(RARA*)Clmd
targeted mutation 1, Cathy Mendelsohn
MGI:4431227
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(RARA*)Clmd/Gt(ROSA)26Sor+
Tg(Hoxb7-cre)13Amc/0
Tg(Hoxb7-EGFP)33Cos/0 		involves: 129/SvEv * C57BL/6 * CBA * Swiss Webster MGI:4431229
cn2
 		Gt(ROSA)26Sortm1(RARA*)Clmd/Gt(ROSA)26Sortm1(RARA*)Clmd
Tg(Hoxb7-cre)13Amc/0
Tg(Hoxb7-EGFP)33Cos/0 		involves: 129/SvEv * C57BL/6 * CBA * Swiss Webster MGI:4431231
cn3
 		Gt(ROSA)26Sortm1(RARA*)Clmd/Gt(ROSA)26Sortm1(RARA*)Clmd
Tg(Hoxb7-cre)13Amc/0 		involves: 129/SvEv * C57BL/6 * Swiss Webster MGI:4431228


Genotype
MGI:4431229
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(RARA*)Clmd/Gt(ROSA)26Sor+
Tg(Hoxb7-cre)13Amc/0
Tg(Hoxb7-EGFP)33Cos/0
Genetic
Background		 involves: 129/SvEv * C57BL/6 * CBA * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(RARA*)Clmd mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)
Tg(Hoxb7-EGFP)33Cos mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal hypoplasia ( J:157254 )
• renal hypoplasia with a 50-80% reduction in branch numbers at E14
impaired branching involved in ureteric bud morphogenesis ( J:157254 )
• 50-80% reduction in branch numbers at E14




Genotype
MGI:4431231
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(RARA*)Clmd/Gt(ROSA)26Sortm1(RARA*)Clmd
Tg(Hoxb7-cre)13Amc/0
Tg(Hoxb7-EGFP)33Cos/0
Genetic
Background		 involves: 129/SvEv * C57BL/6 * CBA * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(RARA*)Clmd mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)
Tg(Hoxb7-EGFP)33Cos mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal hypoplasia ( J:157254 )
• severe renal hypoplasia with reduced branching at E14
absent kidney ( J:157254 )
• renal agenesis at E14
impaired branching involved in ureteric bud morphogenesis ( J:157254 )
• barely begin to branch at E11
• severe renal hypoplasia with reduced branching at E14
small ureteric bud ( J:157254 )
• smaller ureteric bud at E10.5 than in normal embryos




Genotype
MGI:4431228
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(RARA*)Clmd/Gt(ROSA)26Sortm1(RARA*)Clmd
Tg(Hoxb7-cre)13Amc/0
Genetic
Background		 involves: 129/SvEv * C57BL/6 * Swiss Webster
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(RARA*)Clmd mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Hoxb7-cre)13Amc mutation (2 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
abnormal kidney development ( J:157254 )
• few ureteric bud branches or nephrons and severe patterning abnormalities at E14
renal hypoplasia ( J:157254 )
• at E14 the kidneys are greatly reduced in size than normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory