Phenotypes associated with this allele

• Allele Symbol: Col1a1^{tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae}
• Allele Name: targeted mutation 3, Rudolf Jaenisch
• Allele ID: MGI:4430598
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Col1a1^tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/Col1a1^tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae Gt(ROSA)26Sor^tm1(rtTA*M2)Jae/Gt(ROSA)26Sor^tm1(rtTA*M2)Jae	involves: 129S4/SvJae * C57BL/6	MGI:4430610
cx2	Atg5^tm1.1Myok/Atg5^tm1.1Myok Col1a1^tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae/Col1a1^+	involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N	MGI:5572909

Genotype
MGI:4430610

cx1

• Allelic Composition: Col1a1^{tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae}/Col1a1^{tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae}; Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}/Gt(ROSA)26Sor^{tm1(rtTA*M2)Jae}
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:157298 )

• mice exhibit no tumors or health problems up to 31 weeks

Genotype
MGI:5572909

cx2

• Allelic Composition: Atg5^tm1.1Myok/Atg5^tm1.1Myok; Col1a1^{tm3(tetO-Pou5f1,-Sox2,-Klf4,-Myc)Jae}/Col1a1⁺
• Genetic Background: involves: 129S/SvEv * 129S4/SvJae * C57BL/6 * FVB/N

cellular

abnormal cell physiology ( J:205532 )

• mouse embryonic fibroblasts cultured in embryonic stem cell media fail to form induced pluripotent stem cells unlike wild-type cells