skeleton
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• in vertebral cancellous bone at 12 weeks of age
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• 17beta-estradiol has no effect on osteoclast apoptosis unlike in wild-type mice
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• after ovariectomy mice lose cortical bone mass but not cancellous bone mass
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• increase in the number of osteoclasts in vertebral cancellous bone at 12 weeks of age
• at 28 weeks of age, but not at 12 weeks, bone mass is reduced, trabecular width is decreased, and trabecular separation is increased in vertebral cancellous bone
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• the number of osteoclast progenitors is increased 2 fold at 12 weeks of age
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hematopoietic system
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• in vertebral cancellous bone at 12 weeks of age
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• 17beta-estradiol has no effect on osteoclast apoptosis unlike in wild-type mice
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immune system
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• in vertebral cancellous bone at 12 weeks of age
|
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• 17beta-estradiol has no effect on osteoclast apoptosis unlike in wild-type mice
|


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