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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Esr1tm1.1Scma
targeted mutation 1.1, Stavros C Manolagas
MGI:4430564
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Esr1tm1.1Scma/Esr1tm1.1Scma
Lyz2tm1(cre)Ifo/Lyz2+
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6 MGI:4430565


Genotype
MGI:4430565
cn1
Allelic
Composition
Esr1tm1.1Scma/Esr1tm1.1Scma
Lyz2tm1(cre)Ifo/Lyz2+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJaeSor * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Esr1tm1.1Scma mutation (0 available); any Esr1 mutation (67 available)
Lyz2tm1(cre)Ifo mutation (14 available); any Lyz2 mutation (41 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
skeleton
• in vertebral cancellous bone at 12 weeks of age
• 17beta-estradiol has no effect on osteoclast apoptosis unlike in wild-type mice
• after ovariectomy mice lose cortical bone mass but not cancellous bone mass
• increase in the number of osteoclasts in vertebral cancellous bone at 12 weeks of age
• at 28 weeks of age, but not at 12 weeks, bone mass is reduced, trabecular width is decreased, and trabecular separation is increased in vertebral cancellous bone
• the number of osteoclast progenitors is increased 2 fold at 12 weeks of age

hematopoietic system
• in vertebral cancellous bone at 12 weeks of age
• 17beta-estradiol has no effect on osteoclast apoptosis unlike in wild-type mice

immune system
• in vertebral cancellous bone at 12 weeks of age
• 17beta-estradiol has no effect on osteoclast apoptosis unlike in wild-type mice





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory