About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Kdrtm1Wag
targeted mutation 1, Erwin F Wagner
MGI:4422101
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Kdrtm1Wag/Kdrtm1Wag
Nfatc1tm1.1(cre)Bz/Nfatc1+
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+ 		involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6 MGI:5471122
cn2
 		Kdrtm1Wag/Kdrtm1Wag
Nfatc1tm1.1(cre)Bz/Nfatc1+ 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 MGI:5471121
cn3
 		Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+
Kdrtm1Wag/Kdrtm1Wag
Tg(Col2a1-cre)1Bhr/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL MGI:4429126
cn4
 		Kdrtm1Wag/Kdrtm1Wag
Tg(Nes-cre)1Kln/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL MGI:4422209


Genotype
MGI:5471122
cn1
Allelic
Composition		 Kdrtm1Wag/Kdrtm1Wag
Nfatc1tm1.1(cre)Bz/Nfatc1+
Gt(ROSA)26Sortm1Sor/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129S1/Sv * 129S4/SvJaeSor * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (942 available)
Kdrtm1Wag mutation (0 available); any Kdr mutation (71 available)
Nfatc1tm1.1(cre)Bz mutation (0 available); any Nfatc1 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal coronary artery morphology ( J:193198 )
• embryos do not develop intramyocardial coronary arteries
abnormal angiogenesis ( J:193198 )
• at E11.5, endocardial cells cannot respond to Vegf120 and fail to migrate, sprout, and form endothelial networks




Genotype
MGI:5471121
cn2
Allelic
Composition		 Kdrtm1Wag/Kdrtm1Wag
Nfatc1tm1.1(cre)Bz/Nfatc1+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm1Wag mutation (0 available); any Kdr mutation (71 available)
Nfatc1tm1.1(cre)Bz mutation (0 available); any Nfatc1 mutation (47 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, complete penetrance ( J:193198 )
• all die prior to birth (after or during E14.5-16.5)

growth/size/body
decreased body size ( J:193198 )
• observed after E14.5 through 16.5

cardiovascular system
abnormal coronary artery morphology ( J:193198 )
• E14.5 embryos have severely diminished or absent coronary arteries, but coronary veins develop
abnormal angiogenesis ( J:193198 )
• a 24% reduction of subepicardial endothelial cell population (for vein formation) is detected at E14.5, with a 74% decrease in intramyocardial endothelial cells (for artery formation) detected
• E12.5 mutants do not develop coronary plexuses in the peritruncal/coronary sulcus area or ventricular septum
abnormal interventricular septum morphology ( J:193198 )
• E12.5 mutants do not develop coronary plexuses in the ventricular septum
heart hemorrhage ( J:193198 )
• embryos develop cardiac hemorrhages at E14.5-16.5




Genotype
MGI:4429126
cn3
Allelic
Composition		 Gt(ROSA)26Sortm1(Vegfa*)Jhai/Gt(ROSA)26Sor+
Kdrtm1Wag/Kdrtm1Wag
Tg(Col2a1-cre)1Bhr/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * ICR * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Vegfa*)Jhai mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Kdrtm1Wag mutation (0 available); any Kdr mutation (71 available)
Tg(Col2a1-cre)1Bhr mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
skeleton
skeleton phenotype ( J:156474 )
N
• mice do not exhibit severe long bone kyphosis unlike in Gt(ROSA)26Sortm1Jhai Tg(Col2a1-cre)1Bhr mice
abnormal long bone diaphysis morphology ( J:156474 )
• bone shafts in mice are wider than in wild-type mice
abnormal bone structure ( J:156474 )
• mice exhibit hypervascularization in the expanded perichondrial/periosteal region and inside the bone shaft compared with wild-type mice
increased bone mass ( J:156474 )
• mice exhibit an increase in mineralized bone formed compared with wild-type mice that is not as severe as in Gt(ROSA)26Sortm1Jhai Tg(Col2a1-cre)1Bhr mice
abnormal skeleton development ( J:156474 )
• mesenchymal hyperproliferation in mice is reduced compared to in Gt(ROSA)26Sortm1Jhai Tg(Col2a1-cre)1Bhr mice

cardiovascular system
abnormal blood vessel morphology ( J:156474 )
• mice exhibit hypervascularization in the expanded perichondrial/periosteal region and inside the bone shaft compared with wild-type mice




Genotype
MGI:4422209
cn4
Allelic
Composition		 Kdrtm1Wag/Kdrtm1Wag
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdrtm1Wag mutation (0 available); any Kdr mutation (71 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:86207 )
N
• at E13.5, mice exhibit normal developing CNS

behavior/neurological
behavior/neurological phenotype ( J:86207 )
N
• at 1 month, mice exhibit normal behavioral phenotypes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory