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Allele Symbol Allele Name Allele ID |
Pvalbtm1.1(cre)Aibs targeted mutation 1.1, Allen Institute for Brain Science MGI:4421793 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• 50% mortality by 29-35 weeks of age
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• mice develop progressive cued memory deficits, with the difference in freezing response to a conditioned tone becoming significantly different at 15 weeks of age
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• mice show a diminished acoustic startle response
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• mice develop progressive ataxia that is apparent at 6 weeks and worsens by 20 weeks
• however, mice do not exhibit seizures or stereotypical behaviors
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• mice exhibit reduced latency to fall in both the rotarod and dowel walk assays
• mice exhibit impaired performance of the marble-burying test, suggesting forelimb incoordination
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• mice develop widely splayed hind limbs after 10 weeks and hind limb retraction after 15 weeks of age
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• mice spend more time interacting with novel partner mice in a social behavior assay
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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